What is this medication?
Ziprasidone, Zeldox (CDN)/Geodon (US)
Description: Second Generation (Atypical) Antipsychotic
Ziprasidone, Zeldox/Geodon is indicated for schizophrenia; bipolar disorder; agitation/aggression
How does this medication work?
Ziprasidone, Zeldox/Geodon is a benzylisothiazolylpiperazine antipsychotic with the exact mechanism being unknown. Ziprasidone has high affinity for D2, D3, 5-HT2A, 5-HT1A, 5-HT2C, 5-HT1D, and alpha1-adrenergic receptors. It has moderate affinity for histamine H1 receptors. It has minimal to no affinity for alpha2-adrenergic receptors, beta-adrenergic, 5-HT3, 5-HT4, cholinergic, mu, sigma, or benzodiazepine receptors. Ziprasidone functions as an antagonist at the D2, 5-HT2A, and 5-HT1D receptors and as an agonist at the 5-HT1A receptor. Ziprasidone moderately inhibits the reuptake of serotonin and norepinephrine.
How should I take this medication?
Oral: 20 to 80 mg twice daily with meal
How to Take: Administer oral dosage form with a meal containing at least 500 calories. For the injection it is for intramuscular administration only.
You Need to Avoid: Do not stop this medication suddenly, make sure your physician is aware and can create a tapering schedule so you can come off slowly and prevent any withdrawal symptoms. This medication has many drug interactions so ask your pharmacist before starting any over the counter medications or supplements.
What should I watch for while using this medication?
Before starting Ziprasidone, Zeldox/Geodon make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, dementia, an electrolyte imbalance, hepatic impairment, renal impairment, have a seizure disorder, are pregnant, or breastfeeding. Ziprasidone, Zeldox/Geodon use has been associated with rare but serious adverse events such as blood dyscrasias, cerebrovascular effects, CNS depression, dermatologic reactions, dyslipidemia, esophageal dysmotility, aspiration, extrapyramidal symptoms, increased risk of falls, hyperglycemia, hyperprolactinemia, neuroleptic malignant syndrome, orthostatic hypotension, priapism, QT prolongation, suicidal ideation, impaired temperature regulation, and weight gain.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Drowsiness, extrapyramidal reaction, headache, dizziness, nausea, akathisia, anxiety, weight gain, constipation, dyspepsia, xerostomia, weakness, visual disturbance, respiratory tract infection
Note this is not a complete list of side effects, only the most common
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