What is this medication?
Orlistat, Xenical/Alli is officially indicated for obesity management in combination with a reduced calorie diet and to reduce risk of weight regain post loss.
How does this medication work?
Orlistat, Xenical/Alli is a reversible inhibitor of gastric and pancreatic lipases, thus inhibiting absorption of dietary fats by 30%.
How should I take this medication?
Oral: Take 120mg three times daily with each meal containing fat; omit the dose if a meal is missed or contains no fat.
How to Take: Take 1 capsules three times daily with each meal containing fat (during or up to 1 hour after the meal); omit the dose if the meal is missed or contains no fat. Separate taking Xenical by at least 2 hours from multivitamins containing fat-soluble vitamins.
Dietary and Vitamin Considerations When Using Orlistat, Xenical/Alli: Multivitamins that contain fat-soluble vitamins should be taken once daily at least 2 hours before or after administration of Xenical. Gastrointestinal adverse effects can worsen with higher doses and if taken with a meal that contains high amounts of at. Try to distribute your intake of carbohydrates, fat, and protein over three main meals daily.
Is Orlistat, Xenical/Alli Safe to Use During Pregnancy: Any medication used for weight loss is not recommended at conception and during pregnancy. Hence, Xenical is contraindicated in pregnant women.
What should I watch for while using this medication?
Increase risk of cholelithiasis in cases of substantial weight loss
Increase risk of hepatoxicity
Increased levels of urinary oxalate can occur; use with caution in patient with a history of hyperoxaluria or calcium oxalate nephrolithiasis
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
The frequency of side effects is transient and is not well defined.
Cardiovascular: Pedal edema (≤3%)
Central nervous system: Headache (≤31%), fatigue (3% to 7%), anxiety (3% to 5%), sleep disorder (≤4%)
Dermatologic: Xeroderma (≤2%)
Endocrine & metabolic: Menstrual disease (≤10%), hypoglycemia (in patients with diabetes)
Gastrointestinal: Oily rectal leakage (4% to 27%), abdominal distress (≤26%), abdominal pain (≤26%), flatulence with discharge (2% to 24%), bowel urgency (3% to 22%), steatorrhea (6% to 20%), oily evacuation (2% to 12%), frequent bowel movements (3% to 11%), nausea (4% to 8%), fecal incontinence (2% to 8%), infectious diarrhea (≤5%), rectal pain (3% to 5%), gingival disease (4%), cholelithiasis (3%), abdominal distension (in patients with diabetes)
Genitourinary: Urinary tract infection (6% to 8%), vaginitis (3%)
Infection: Influenza (≤40%)
Neuromuscular & skeletal: Back pain (≤14%), leg pain (≤11%), myalgia (≤4%)
Otic: Otitis (4%)
Respiratory: Upper respiratory tract infection (38%), lower respiratory tract infection (≤8%)
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