What is this medication?
Antineoplastic Agent, Antimetabolite (Pyrimidine Analog)
Capecitabine, Xeloda is officially indicated for colorectal cancer, Breast cancer (metastatic)
“ALERT: US Boxed Warning
Patients receiving concomitant capecitabine and oral coumarin-derivative anticoagulant therapy should have their anticoagulant response (INR or PT) monitored frequently in order to adjust the anticoagulant dose accordingly. A clinically important capecitabine-warfarin drug interaction was demonstrated in a clinical pharmacology trial. Altered coagulation parameters and/or bleeding, including death, have been reported in patients taking capecitabine concomitantly with coumarin-derivative anticoagulants such as warfarin and phenprocoumon. Postmarketing reports have shown clinically significant increases in PT and INR in patients who were stabilized on anticoagulants at the time capecitabine was introduced. These events occurred within several days and up to several months after initiating capecitabine therapy and, in a few cases, within 1 month after stopping capecitabine. These events occurred in patients with and without liver metastases. Age >60 years and a diagnosis of cancer independently predispose patients to an increased risk of coagulopathy.”
How does this medication work?
Capecitabine, Xeloda is a prodrug of fluorouracil that is converted by undergoing hydrolysis in the liver and tissues. Fluorouracil, the active moiety is a fluorinated pyrimidine antimetabolite that inhibits thymidylate synthetase, blocking the methylation of deoxyuridylic acid to thymidylic acid, interfering with DNA, and to a lesser degree, RNA synthesis. Fluorouracil appears to be phase specific for the G1 and S phases of the cell cycle.
How should I take this medication?
Oral: 1,250 mg/m2 twice daily for 2 weeks, every 21 days. Lower dosage may be considered to reduce risk of toxicity.
How to Take: Usually administered in 2 divided doses (in the morning and evening). Doses should be taken with water within 30 minutes after a meal. Swallow tablets whole. Avoid cutting or crushing tablets.
What should I watch for while using this medication?
Before starting Capecitabine, Xeloda sure your physician is aware of any allergies or medications you currently take, if you have kidney disease, liver disease, or are lacking activity of the enzyme dihydropyridine dehydrogenase. Capecitabine, Xeloda use has been associated with rare but serious adverse reactions such as bone marrow suppression, cardiotoxicity, dermatologic toxicity, gastrointestinal toxicity, hand and foot syndrome, and hepatotoxicity.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Edema, fatigue, paresthesia, pain, palmar-plantar eythrodysesthesia, dermatitis, diarrhea, nausea, vomiting, abdominal pain, decreased appetitive, stomatitis, anorexia, constipation, lymphocytopenia, anemia, neutropenia, thrombocytopenia, hyperbilirubinemia, asthenia, eye irritation, fever
Note this is not a complete list of side effects for Capecitabine, Xeloda only common ones.
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