What is this medication?
Antifungal, Azole Derivative
Voriconazole, Vfend is indicated for treatment of fungal infections.
How does this medication work?
Voriconazole, Vfend inhibits ergosterol synthesis via action on cytochrome P450 activity, resulting in interfered fungal cell membrane formation.
How should I take this medication?
Oral: 200 to 300 mg twice daily or weight-based dosing (3 to 4 mg/kg twice daily)
Therapeutic drug monitoring: Adjust dose based on serum trough concentration to ensure efficacy and avoid toxicity. Timing and frequency of concentration monitoring is individualized
How to Take: Infuse over 1 to 3 hours (rate not to exceed 3 mg/kg/hour). May be infused simultaneously with nonconcentrated electrolytes or TPN through a separate IV line. If TPN is infused through a multiple lumen catheter, use a different port than used for voriconazole. For oral use, administer 1 hour before or 1 hour after a meal. Shake oral suspension for approximately 10 seconds before each use. Enteral tube feedings may decrease oral absorption; may hold tube feedings for 1 hour before and 1 hour after a voriconazole dose.
What should I watch for while using this medication?
Before starting Voriconazole, Vfend make sure your physician is aware of any allergies or medications you currently take, if you have kidney disease, liver disease, an electrolyte imbalance, pancreatitis, are pregnant, or breastfeeding. Voriconazole, Vfend use has been associated with rare but serious side effects such as cardiac arrythmia/QT prolongation, severe dermatologic reactions, hepatotoxicity, infusion-related reactions, adverse ocular effects, renal toxicity, and adverse skeletal effects.
You Need to Avoid: This medication has many drug interactions so make sure to ask your physician or pharmacist before using any over the counter medications or herbal supplements. Do not administer as an IV bolus injection. Do not infuse concomitantly into same line or cannula with other drug infusions. Do not infuse concomitantly even in separate lines or cannulas with concentrated electrolyte solutions or blood products.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Hypertension, skin rash, hyperkalemia, hypokalemia, vomiting, nausea, abdominal pain, diarrhea, increased serum alkaline phosphatase, increased serum alanine aminotransferase, increased liver enzymes, increased serum aspartate aminotransferase, hyperbilirubinemia, visual disturbance, increased serum creatinine, epistaxis, fever
Note this is not a complete list of side effects, only the most common ones
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