What is this medication?
Antineoplastic Agent; BCL-2 Inhibitor
Venetoclax, Venclexta is officially indicated for acute myeloid leukemia, chronic lymphocyte leukemia/small lymphocytic lymphoma
How does this medication work?
Venetoclax, Venclexta restores the apoptosis in tumor cells by binding directly to the BCL-2 protein, displacing pro-apoptotic proteins, leading to mitochondrial outer membrane permeabilization and the activation of caspase enzymes.
How should I take this medication?
The initial and ramp-up schedule/dose varies by indication.
Note: Assess risk for tumor lysis syndrome (TLS); administer prophylactic hydration and antihyperuricemics prior to the first venetoclax dose (see Premedications). TLS may also occur upon venetoclax reinitiation following therapy interruption.
How to Take (Oral): Administer with a meal and water at approximately the same time each day. Swallow whole; do not crush, chew, or break prior to administration.
What should I watch for while using this medication?
Before using Venetoclax, Venclexta make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Venetoclax, Venclexta has been reported to cause neutropenia, thrombocytopenia, and anemia. Serious and fatal infections, including pneumonia and sepsis, have occurred with venclexta. Tumor lysis syndrome (TLS) has also occurred in patients with high tumor burden when treated with Venetoclax, Venclexta.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Edema, fatigue, headache, dizziness, skin rash, hypocalcemia, hyperglycemia, hyperkalemia, decreased serum albumin, hypophosphatemia, hyponatremia, hyperphosphatemia, diarrhea, nausea, abdominal pain, constipation, vomiting, stomatitis, leukopenia, neutropenia, lymphocytopenia, anemia, thrombocytopenia, tumor lysis syndrome, increased serum aspartate aminotransferase, musculoskeletal pain, arthralgia, upper respiratory tract infection, cough, pneumonia, dyspnea, lower respiratory tract infection, fever
Note this is not a complete list of side effects, only the most common.
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