What is this medication?
Prostacyclin; Prostacyclin IP Receptor Agonist; Vasodilato
Selexipag, Uptravi is officially indicated for pulmonary arterial hypertension
How does this medication work?
Patients with pulmonary arterial hypertension appear to have a dysregulation in the prostacyclin metabolic pathways and Selexipag, Uptravi is a selective prostacyclin IP receptor agonist. Prostacyclin is produced in the endothelial cells and induces vasodilation and inhibits platelet aggregation.
How should I take this medication?
Oral: 200 – 1600 mcg twice daily. If a dose is not tolerated, reduce dose to previously tolerated dose.
How to Take: Administer with or without food; tolerability may be improved when taken with food. Swallow tablets whole; do not split, crush, or chew.
What should I watch for while using this medication?
Before starting Selexipag, Uptravi make sure your physician is aware of any allergies or medications you currently take, if you have hepatic impairment, are pregnant, or breastfeeding. Selexipag, Uptravi use has been associated with rare but serious adverse events such as pulmonary edema.
What if I miss a dose?
If dose is missed, take dose as soon as possible unless the next dose is within the next 6 hours. If ≥3 days of treatment are missed, restart at a lower dose and then retitrate.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Flushing, headache, skin rash, diarrhea, nausea, vomiting, jaw pain, limb pain, myalgia, arthralgia, decreased appetite, decreased hemoglobin, anemia
Note this is not a complete list of side effects, only the most common
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