What is this medication?
Antineoplastic Agent, Tyrosine Kinase Inhibitor
Officially indicated for the treatment of breast cancer, HER2 positive, advanced, unresectable or metastatic
How does this medication work?
Tucatinib, Tukysa is a tyrosine kinase inhibitor that binds to human epidermal growth factor receptor 2 (HER2) and subsequently inhibits MAPK and AKT signaling and cancer cell proliferation to help stop or slow the spread of cancer.
How should I take this medication?
Usual (Oral): 300mg twice daily in combination with trastuzumab and capecitabine until disease progression or until toxicity occurs.
How to Take: Take with or without food, every 12 hours. Swallow tablets whole; do not crush, chew or split. Can take tucatinib, Tukysa at the same time as capecitabine in the days that capecitabine is also scheduled.
What should I watch for while using this medication?
Before starting Tucatinib, Tukysa make sure your physician is aware of any allergies or medications you currently take, and current medical conditions. Tucatinib, Tukysa (in combination with capecitabine and trastuzumab) should not be used in patients with severe renal impairment.
What if I miss a dose?
If a dose is missed or vomited, administer the next dose at its usual time.; do not double the dose the next day.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Palmar-plantar erythrodysesthesia, skin rash, electrolyte disturbances, weight loss, abdominal pain, severe diarrhea, nausea, stomatitis, vomiting, anemia, hepatotoxicity, fatigue, headache, peripheral neuropathy, joint pain, and epistaxis.
Tucatinib, Tukysa can cause diarrhea, including severe diarrhea accompanied by dehydration, hypotension, acute kidney injury which can lead to death.
Tucatinib, Tukysa has been reported to cause hepatotoxicity and should be used with caution in patients with pre-existing hepatic impairment.
- Choosing a selection results in a full page refresh.
- Press the space key then arrow keys to make a selection.