TRUVADA (Emtricitabine/Tenofovir)

TRUVADA (Emtricitabine/Tenofovir)

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GILEAD SCIENCES
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prescription

What is this medication?

Emtricitabine+Tenofovir, Truvada
Antiretroviral, Reverse Transcriptase Inhibitor

Emtricitabine+Tenofovir is indicated for treatment of HIV-1 Infection.

“Alert: Black Box Warning

Posttreatment acute exacerbation of hepatitis B:
Severe, acute exacerbations of hepatitis B virus (HBV) have been reported in HBV-infected individuals who have discontinued emtricitabine/tenofovir disoproxil fumarate. Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in individuals who are infected with HBV and discontinue emtricitabine/tenofovir disoproxil fumarate. If appropriate, initiation of antihepatitis B therapy may be warranted.

Risk of drug resistance with use for preexposure prophylaxis:
Emtricitabine/tenofovir disoproxil fumarate used for HIV-1 preexposure prophylaxis must only be prescribed to individuals confirmed to be HIV-negative immediately prior to initiating and at least every 3 months during use. Drug-resistant HIV-1 variants have been identified with use of emtricitabine/tenofovir disoproxil fumarate for HIV-1 preexposure prophylaxis following undetected acute HIV-1 infection. Do not initiate emtricitabine/tenofovir disoproxil fumarate for HIV-1 preexposure prophylaxis if signs or symptoms of acute HIV-1 infection are present unless negative infection status is confirmed.”

How does this medication work? 

Emtricitabine is a nucleoside reverse transcriptase inhibitor; cytosine analogue that is phosphorylated intracellularly to emtricitabine 5′-triphosphate which interferes with HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication.

Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor; analog of adenosine 5′-monophosphate that interferes with the HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication. TDF is first converted intracellularly by hydrolysis to tenofovir and subsequently phosphorylated to the active tenofovir diphosphate. Tenofovir inhibits replication of HBV by inhibiting HBV polymerase.

How should I take this medication? 

Oral: Take 1 tablet once daily.

How to Take: with or without food

What should I watch for while using this medication?

Before starting Emtricitabine+Tenofovir, Truvada make sure your physician is aware of any allergies or medications you currently take, or if you have chronic hepatitis B infection.  Emtricitabine+Tenofovir, Truvada use has been associated rare but serious adverse events such as a decrease in bone mineral density, immune reconstitution syndrome, lactic acidosis/hepatomegaly, osteomalacia, and renal toxicity.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Decreased bone mineral density, headache, weight loss, abdominal pain, decreased neutrophil count, abnormal serum phosphorus, insomnia, dizziness, depression, rash, hypercholesteremia, cough, rhinitis, weakness, diarrhea, nausea 

Note this is not a complete list of side effects, only common ones.