What is this medication?
Antiretroviral, Reverse Transcriptase Inhibitor (Anti-HIV)
“Alert: US Warning
Trizivir has been associated with hematologic toxicity including neutropenia and severe anemia in advanced HIV-1 disease. Prolonged use of Trizivir has been shown to cause symptomatic myopathy. Lactic acidosis and severe hepatomegaly with steatosis have been reported with using nucleoside analogues. Severe exacerbations of hepatitis B have been reported in patients who are coinfected with hepatitis B virus (HBV) and HIV-1.”
How does this medication work?
Trizivir is a combination of abacavir, lamivudine, and zidovudine which act synergistically through different mechanisms of action to inhibit reverse transcriptase to reduce viral replication and to delay the emergence of mutations conferring resistance. Abacavir is a guanosine analogue which is phosphorylated to carbovir triphosphate which interferes with HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication. Lamivudine is a cytosine analog. In vitro, lamivudine is triphosphorylated, the principal mode of action is inhibition of HIV reverse transcription via viral DNA chain termination; inhibits RNA- and DNA-dependent DNA polymerase activities of reverse transcriptase. In hepatitis B, the monophosphate form of lamivudine is incorporated into the viral DNA by hepatitis B virus polymerase, resulting in DNA chain termination. Zidovudine is a thymidine analog which interferes with the HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication; nucleoside reverse transcriptase inhibitor.
How should I take this medication?
Usual (Oral): One tablet (abacavir 300mg/lamivudine 150mg/zidovudine 300mg) twice daily.
Note: Triple NRTI regimens are not recommended in HIV treatment guidelines due to suboptimal virologic activity.
How to Take: Take without regard to meals.
What should I watch for while using this medication?
Before starting Abacavir+Lamivudine+Zidovudine, Trizivir make sure your physician is aware of any allergies or medications you currently take, and activities you perform. Abacavir+Lamivudine+Zidovudine, Trizivir have been associated with series adverse reactions including hematologic toxicity, including neutropenia and severe anemia. Hypersensitivity reactions have occurred in patients taking Trizivir. Patient’s who carry the HLA-B*5701 allele have been found to be at higher risk for a hypersensitivity reaction. Abacavir+Lamivudine+Zidovudine, Trizivir can trigger the development of an immune reconstitution syndrome which can result in an inflammatory response to an indolent or residual infection. Abacavir+Lamivudine+Zidovudine, Trizivir can also cause lactic acidosis, severe hepatomegaly, lipoatrophy, myopathy and pancreatitis. Abacavir+Lamivudine+Zidovudine, Trizivir should be used with caution in patients with coronary heart disease, hepatic and/or renal impairment.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Headache, fatigue, malaise, depression, anxiety, skin rash, nausea, diarrhea, pancreatitis, neutropenia, increased serum ALT, hypersensitivity, viral infection, fever and chills, increased creatine phosphokinase.
Note this is not a complete list of side effects, only the most common.
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