What is this medication?
Anti-Parkinson Agent, Anticholinergic; Anticholinergic Agent
Trihexyphenidyl is indicated for treatment of drug-induced extrapyramidal symptoms; Parkinsonism
How does this medication work?
Trihexyphenidyl has a direct inhibitory effect on the parasympathetic nervous system. It also has a relaxing effect on smooth musculature via both direct action on the muscle itself and indirectly through parasympathetic nervous system.
How should I take this medication?
Oral: Initial: 1 mg/day; increase as necessary to usual range: 5 to 15 mg/day in 3 to 4 divided doses.
How to Take: May be administered before or after meals (if excessive dry mouth develops, consider administering before meals unless it causes nausea; postencephalitic patients who are prone to excessive salivation may prefer to take after meals); tolerated best if given in 3 daily doses and with food. High doses (>10 mg/day) may be divided into 4 doses (at each meal and at bedtime). May be taken before or after meals; tolerated best if given with food.
What should I watch for while using this medication?
Before starting Trihexyphenidyl make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, a GI obstruction, glaucoma, hepatic impairment, prostatic hyperplasia/urinary stricture, have cognitive impairment, a psychiatric disorder, renal impairment, are pregnant, or breastfeeding. Trihexyphenidyl use has been associated with rare but potentially serious adverse events such as anhidrosis/hyperthermia, anticholinergic effects, CNS depression, and precipitation of narrow angle glaucoma.
You Need to Avoid: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber. Prophylactic use is generally not recommended to prevent antipsychotic-associated extrapyramidal symptoms Have prescriber reduce dosage gradually if needed as dose reduction or discontinuation of trihexyphenidyl has been associated with neuroleptic malignant syndrome (NMS), exacerbation of Parkinsonism, and withdrawal symptoms including tension, irritability, perspiration, palpitations, headache, insomnia, abdominal distress, anorexia, faint or choking feelings, nausea, and photophobia.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Tachycardia, agitation, confusion, delusions, dizziness, drowsiness, euphoria, hallucination, headache, nervousness, paranoia, psychiatric disturbance, skin rash, constipation, intestinal obstruction, nausea, parotitis, toxic megacolon, vomiting, xerostomia, urinary retention, weakness, blurred vision, glaucoma, increased intraocular pressure, mydriasis
Note the frequency of side effects has not been determined in clinical trials.
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