What is this medication?
Antianginal Agent; Antiarrhythmic Agent, Antihypertensive; Calcium Channel Blocker
Diltiazem, Cardizem/Tiazac is officially indicated for treatment of hypertension, stable angina, atrial fibrillation/flutter for acute ventricular control
How does this medication work?
Diltiazem, Cardizem, Tiazac is a calcium channel blocker that blocks the entry of calcium ions into the cardiac smooth muscle during depolarization. The reduced levels of intracellular calcium lead to smooth muscle relaxation and subsequently vasodilation and a reduction in blood pressure.
How should I take this medication?
Oral Immediate Release: Initial 30mg 4 times daily and increase to a maintenance dose of 240mg to 360mg daily in 3 to 4 divided doses.
Oral 12-hour formulation: Initial 60mg twice daily and increase to a maintenance dose of 240mg to 360mg daily in 2 divided doses.
Oral 24-hour formulation: Initial 120mg to 180mg once daily and increase to a maintenance dose of 240mg to 360mg daily.
Note: Avoid in patients taking a beta-blocker or who have heart failure with reduced ejection fraction, sinus node dysfunction, or second- or third-degree atrioventricular block unless a functioning pacemaker has been placed.
How to Take:
Oral Immediate Release: Take before meals and at bedtime. Do not crush, split or chew the film coated tablets. However, brand name Cardizem states that the tablets be crushed or chewed not split.
Oral Long-Acting: Take either in the morning or in the evening, same time each day. Do not open, chew or crush the capsules, swallow whole.
What should I watch for while using this medication?
Before starting Diltiazem, Cardizem/Tiazac make sure your physician is aware of any allergies medications you currently take. There have been cases of first-, second-, and third-degree AV block or sinus bradycardia. Dermatologic reactions including Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, and/or exfoliative dermatitis have been reported as well.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
The incidence of side effects is dependent upon the patient’s cardiovascular function upon starting therapy. Peripheral edema is by far the most common side effect and is dose related.
Note this is not a complete list of side effects, only common ones.
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