What is this medication?
Temozolomide, Temodal (CDN) /Temodar (US)
Brand Name US: Temodar
Canadian Equivalent: Temodal
Temozolomide, Temodal/Temodar is officially indicated for refractory anaplastic astrocytoma, and for new diagnoses of glioblastoma. It is also prescribed off-label for various other forms of cancer. (may be used for conditions not listed)
How does this medication work?
Temozolomide is a prodrug that is quickly converted to the active alkylating metabolite MTIC [(methyl-triazene-1-yl)-imidazole-4-carboxamide)]. The conversion is spontaneous, nonenzymatic, and occurs under physiologic conditions in all tissues. The cytotoxic effects of MTIC are manifested through alkylation (methylation) of DNA at specific sites leading to DNA breakdown and cell apoptosis.
How should I take this medication?
Dosing for this medication is very complex and is calculated based on body surface area and varies with the form and severity of cancer it is being used to treat. It is generally dosed in cycles and is most commonly in an oral form, however IV infusions are also available.
How to Take: Can take with or without food, but must remain consistent
What should I watch for while using this medication?
Before starting Temozolomide, Temodal/Temodar make sure your physician is aware of any allergies or medications you currently take. Temozolomide, Temodal/Temodar has been associated with a number of serious health events including bone marrow suppression, severe nausea, liver toxicity, increased risk of certain forms of pneumonia and occurrence of secondary malignancies.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Cardiovascular: Peripheral edema (11%)
Dermatologic: Alopecia (55%), skin rash (8% to 13%)
Gastrointestinal: Nausea (49% to 53%), vomiting (29% to 42%), constipation (22% to 33%), anorexia (9% to 27%), diarrhea (10% to 16%)
Hematologic & oncologic: Lymphocytopenia (grades 3/4: 55%), thrombocytopenia (8%; grades 3/4: 4% to 19%), decreased neutrophils (grades 3/4: 14%), leukopenia (grades 3/4: 11%)
Infection: Viral infection (11%)
Nervous system: Fatigue (34% to 61%), headache (23% to 41%), seizure (6% to 23%), hemiparesis (18%), dizziness (5% to 12%), ataxia (8% to 11%)
Neuromuscular & skeletal: Asthenia (7% to 13%)
Miscellaneous: Fever (13%)
Note this is not a complete list of side effects, only common ones.
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