What is this medication?
Carbamazepine, Tegretol is indicated for treatment of bipolar disorder, focal (partial) onset seizures and generalized onset seizures, neuropathic pain.
“Alert: Black Box Warning
The risk of developing anemia or agranulocytosis is increased during treatment. Complete pretreatment hematological testing should be obtained prior to use; monitor patient closely if white blood cells or platelet counts decrease during therapy; discontinue if significant bone marrow suppression occurs.
Severe and sometimes fatal dermatologic reactions, including toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS), may occur during therapy. The risk is increased in patients with the variant HLA-B*1502 allele, found most often in patients of Asian ancestry. Patients with an increased likelihood of carrying this allele should be screened prior to initiating therapy. Avoid use in patients testing positive for the allele; discontinue therapy in patients who have a serious dermatologic reaction. “
How does this medication work?
Carbamazepine, Tegretol is a sodium channel block which prevent repetitive and sustained action potentials in the neuronal membrane leading to a reduction in synaptic neuronal transmission in the central nervous system. Carbamazepine, Tegretol has also been shown to exhibit in addition to anticonvulsant properties, anticholinergic, antineuralgic, antidiuretic, muscle relaxant, antimanic, antidepressive, and antiarrhythmic properties.
How should I take this medication?
Oral: 100mg to 1800mg daily in divided doses depending on achieving the optimal response to therapy.
How to Take:
Chewable or Immediate Release Tablets: Take with food.
ER Capsule: Consists of three different types of beads: immediate release, extended release, and enteric release. The bead types are combined in a ratio to allow twice daily dosing. May be opened and contents sprinkled over food such as a teaspoon of applesauce; may be administered with or without food; do not crush or chew capsule or beads inside capsule.
ER Tablet: Should be inspected for damage. Damaged ER tablets (without release portal) should not be administered. Should be administered with meals; swallow whole, do not crush or chew.
Suspension: Shake well before administration. Must be given on a 3 to 4 times/day schedule versus tablets, which can be given 2 to 4 times/day. Because a given dose of suspension will produce higher peak and lower trough levels than the same dose given as the tablet form, patients given the suspension should be started on lower doses given more frequently (same total daily dose) and increased slowly to avoid unwanted side effects. When carbamazepine suspension has been combined with chlorpromazine or thioridazine solutions, a precipitate form, which may result in loss of effect. Therefore, it is recommended that the carbamazepine suspension dosage form not be administered at the same time with other liquid medicinal agents or diluents. Should be administered with meals.
What should I watch for while using this medication?
Before starting Carbamazepine, Tegretol make sure your physician is aware of any allergies or medications you currently take and is prepared to monitor you thoroughly while on Carbamazepine, Tegretol. You can experience drowsiness, agitation, and suicidal ideation. There are serious side effects associated with taking Carbamazepine, Tegretol such as blood dyscrasias, dermatologic toxicity, hepatic and renal toxicity, and multi-organ hypersensitivity reactions.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Dizziness, drowsiness, ataxia, nausea, vomiting
Note this is not a complete list of side effects for Carbamazepine, Tegretol only common ones.
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