What is this medication?
Dimethyl Fumarate, Tecfidera
Fumaric Acid Derivative
Tecfidera is officially indicated for treatment of relapsing multiple sclerosis.
How does this medication work?
DMF and its active metabolite, monomethyl fumarate (MMF), have been shown to activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway, which is involved in cellular response to oxidative stress. The mechanism by which dimethyl fumarate (DMF) exerts a therapeutic effect in MS is unknown, although it is believed to result from its anti-inflammatory and cytoprotective properties via activation of the Nrf2 pathway.
How should I take this medication?
Oral: 120mg twice daily for 7 days then increase to the maintenance dose of 240mg twice daily.
How to Take: Do not crush, chew, or open the capsules; swallow the capsules whole. Can be taken with or without food. If you experience flushing, you can try taking with a high-fat meal/food or take an aspirin (non-enteric coated up to a dose of 325mg) 30 minutes prior.
What should I watch for while using this medication?
Before starting dimethyl fumarate, Tecfidera make sure your physician is aware of any allergies or medications you currently take. You may experience a rash, itchiness and redness of the skin and are at a higher risk of developing herpes zoster and other infections when on dimethyl fumarate, Tecfidera.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Flushing, abdominal pain, diarrhea, nausea, and infection(s).
Note this is not a complete list of side effects, only common ones.
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