What is this medication?
Anti-interleukin 17A Monoclonal Antibody; Antipsoriatic Agent, Monoclonal Antibody
Ankylosing spondylitis, plaque psoriasis, psoriatic arthritis
“Alert: Black Box Warning
Patients treated with Ixekizumab are at an increased risk of developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants, such as methotrexate or corticosteroids.
Discontinue Ixekizumab if a patient develops a serious infection or sepsis.
Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with tumor necrosis factor (TNF) blockers, including Ixekizumab.”
How does this medication work?
Ixekizumab is a humanized IgG4 monoclonal antibody that selectively binds with the interleukin 17A (IL-17A) cytokine and inhibits its interaction with the IL-17 receptor. IL-17A is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Ixekizumab inhibits the release of proinflammatory cytokines and chemokines.
How should I take this medication?
Initial Dose: Subcutaneous
Inject 160mg as a single dose
Maintenance Dose: Subcutaneous
Inject 80mg every 2 to 4 weeks depending on indication.
How to Take: Do not shake. Inject full amount into the upper arms, thighs, or any quadrant of the abdomen; administer each injection at a different anatomic location than a previous injection and avoid areas where the skin is tender, bruised, erythematous, indurated, or affected by psoriasis. Administration in the upper, outer arm may be performed by a caregiver or health care provider.
Note: Ixekizumab may be self-injected by the patient or caregiver following proper training in subcutaneous injection technique.
What should I watch for while using this medication?
Before starting Ixekizumab, Taltz make sure your physician is aware of any allergies or medications you currently take, you may be at an increased risk an infection and can in some patients exacerbate Crohn disease and ulcerative colitis.
What if I miss a dose?
Call your doctor or pharmacist for instructions.
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store the medicine in the original carton until you are ready to use it, in the refrigerator between 36°F to 46°F (2°C to 8°C). You may also store this medicine at room temperature up to 30°C for up to 5 days. Do not put it back in the refrigerator once stored at room temperature. Throw away any unused medicine after 5 days.
What are the possible side effects of using this medication?
Neutropenia, antibody development, infection, injection site reaction, upper respiratory tract infection.
Note this is not a complete list of side effects for Ixekizumab, Taltz only common ones.
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