What is this medication?
Antineoplastic Agent, Epidermal Growth Factor Receptor (EGFR) Inhibitor; Tyrosine Kinase Inhibitor
Osimertinib is indicated for treatment of non-small cell lung cancer; metastatic.
How does this medication work?
Osimertinib, Tagrisso is an irreversible Epidermal Growth Factor Receptor (EGRF) Inhibitor in addition to inhibiting tyrosine kinase autophosphorylation and thus blocking the activity of downstream signaling pathways related to growth and apoptosis suppression. It binds to select mutant forms of EGFR, including T790M, L858R, and exon 19 deletion at lower concentrations than wild-type. Osimertinib exhibits less activity against wild-type EGFR (as compared to other EGFR inhibitors) and is selective for sensitizing mutations and the T790M resistance mutation, which is the most common mechanism of resistance to EGFR tyrosine kinase inhibitors.
How should I take this medication?
Oral: 80 mg once daily until disease progression or unacceptable toxicity
How to Take: May be administered with or without food. For patients who have difficulty swallowing tablets, disperse tablet in 60 mL of noncarbonated water (only), stir until tablet is dispersed into small pieces (will not dissolve completely) and immediately swallow. Rinse container with 120 to 240 mL of water and immediately drink).
You Need to Avoid: Do not crush, heat, or ultrasonicate during preparation of solution.
What should I watch for while using this medication?
Before starting Osimertinib, Tagrisso make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding. Osimertinib, Tagrisso use has been associated with rare but serious adverse events such as bone marrow suppression, cardiovascular toxicity, cutaneous toxicity, fertility effects, GI toxicity, ocular toxicity, and pulmonary toxicity.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Skin rash, xeroderma, nail disease, pruritis, hypermagnesemia, hypokalemia, diarrhea, stomatitis, decreased appetite, constipation, nausea, vomiting, lymphocytopenia, anemia, thrombocytopenia, neutropenia, increased serum aspartate aminotransferase, increased serum alanine aminotransferase, hyperbilirubinemia, fatigue, headache, cough, dyspnea
Note this is not a complete list of side effects, only the most common ones.
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