TABLOID/LANVIS (Thioguanine)

What is this medication?

Thioguanine, Tabloid (US)/Lanvis (CDN)
Antineoplastic Agent, Antimetabolite

Brand Name US: Tabloid
Canadian Equivalent: Lanvis

Thioguanine, Tabloid/Lanvis is indicated for treatment of acute myeloid leukemia.

How does this medication work?

Thioguanine, Tabloid/Lanvis is a purine analog of guanine that is incorporated into DNA and RNA resulting in the blockage of synthesis and metabolism of purine nucleotides. Thioguanine, Tabloid/Lanvis works by slowing or stopping the growth of the cancer cells.

How should I take this medication?

Usual (Oral): 2mg/kg once daily for 4 weeks. May increase dose to 3mg/kg once daily with careful monitoring if no clinical improvement is shown

How to Take: Daily dose can be taken at one time

What should I watch for while using this medication?

Before starting Thioguanine, Tabloid/Lanvis make sure your physician is aware of any allergies or medications you currently take. Like most chemotherapeutic drugs, Thioguanine, Tabloid/Lanvis use has been associated with rare but serious adverse events such as bone marrow suppression, hepatotoxicity, photosensitivity, secondary malignancies, and tumor lysis syndrome.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

The frequency and incidence of side effects is not well defined but do include:

Esophageal varices, portal hypertension, fluid retention, hyperuricemia, increased gamma-glutamyl transferase, weight gain, anorexia, intestinal necrosis, intestinal perforation, nausea, stomatitis, vomiting, anemia, bone marrow depression, granulocytopenia, hemorrhage, leukopenia, pancytopenia, splenomegaly, thrombocytopenia, ascites, hepatic disease, hepatic focal nodular hyperplasia, hepatic necrosis, hepatic sinusoidal obstruction syndrome, hepatomegaly, hepatotoxicity, hyperbilirubinemia, increased liver enzymes, increased serum alkaline phosphatase, jaundice, peliosis hepatitis, periportal fibrosis, infection, bone hypoplasia.