What is this medication?
Antidiabetic Agent; Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
Indicated for treatment of diabetes mellitus, type 2.
How does this medication work?
SGLT2 is in the proximal renal tubules of the nephron (a functional unit of the kidney) and is the main site of reabsorption of filtered glucose. Ertugliflozin, Steglatro inhibits this transporter which lowers glucose reabsorption and lowers the renal threshold for glucose resulting in its urinary excretion thereby lowering plasma glucose concentrations.
How should I take this medication?
Initial (Oral): 5mg to 15mg once daily
How to Take: Take consistently at same time each day in the morning without regard to meals. Store at room temperature. Monitor blood pressure when initiating due to diuretic effect.
You Need to Avoid: Do not skip standard diabetic foot care regimen. Must monitor for wounds or signs of new infection, ulcers, sores or new pain or tenderness. A trial involving a similar medication (canagliflozin) showed a higher frequency of lower limb amputations compared to placebo so caution must be taken. There is no direct evidence of empagliflozin having this effect but due to similarities it should be taken seriously. Avoid volume depletion or dehydration due to diuretic effect of this medication.
What should I watch for while using this medication?
Before starting Ertugliflozin, Steglatro make sure your physician is aware of any allergies, medications you currently take, if you have kidney disease, liver disease, heart failure, a history of diabetic ketoacidosis, have had bariatric surgery, are pregnant or breastfeeding. Ertugliflozin, Steglatro has been associated with rare but serious adverse reactions such as increased risk of bone fracture, genital mycotic infections, hypotension, ketoacidosis, increased risk of lower limb amputation, necrotizing fasciitis, renal effects, and urinary tract infections.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Genitourinary fungal infection, headache, hypovolemia, hypoglycemia, increased thirst, weight loss, severe hypoglycemia, increased urine output, vulvovaginal pruritus, back pain, renal insufficiency, nasopharyngitis
Note this is not a complete list of side effects, only the most common.
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