What is this medication?
Phosphodiesterase-5-Inhibitor for Erectile Dysfunction
Vardenafil, Levitra/Staxyn is indicated for the treatment of erectile dysfunction or organic, psychogenic, or mixed etiology
How does this medication work?
Vardenafil/Levitra/Staxyn enhances the physiological erectile response following sexual arousal through the potentiation of nitric oxide effects on vascular smooth muscle. Nitric oxide is released into the corpus cavernosum in response to sexual stimulation. This stimulates the production of cGMP, leading to smooth muscle relaxation and subsequently vasodilation and erection of the penis. Vardenafil/Levitra/Staxyn selectively inhibits cGMP for PDE5 which is main enzyme that metabolizes cGMP in the penis, thus enhancing the erectile response of the penis.
How should I take this medication?
Film coated tablet (Levitra): Take 10mg once daily as needed, can be taken 1 hour before sexual activity. Reduce the dose down to 5mg if you experience any side effects. May increase the dose to a maximum daily dose of 20mg if not satisfied with erectile response to sexual stimulation.
Oral disintegrating tablet (Staxyn): Take 10mg once daily as needed, can be taken 1 hour before sexual activity. The maximum recommended daily dose is 10mg.
Take 10mg twice daily.
How to Take: Do not split the tablet; take the entire tablet and swallow whole on an empty stomach. When used as needed, take at least 60 minutes prior to sexual activity. When used as once daily basis, try to take the same time each day regardless of sex.
What should I watch for while using this medication?
Use with caution or avoid in persons with increased susceptibility to vasodilators including those with aortic stenosis, cardiomyopathy, and impaired autonomic control of blood pressure.
Use with caution in persons who have suffered a myocardial infarction, stroke, or life-threatening arrhythmia within the last six months.
Use with caution in persons with resting hypotension (blood pressure under 90/50) or hypertension (blood pressure 170/110).
Use with caution in persons with heart failure or coronary artery disease.
You Need to Avoid (Vardenafil/Levitra/Staxyn): Avoid large amounts of grapefruit and its juice (CYP3A4 inhibitor) and alcohol which may enhance the hypotensive effect.
If You Experience Chest Pain (Vardenafil/Levitra/Staxyn): Seek medical attention immediately.
If You Experience Hearing Loss (Vardenafil/Levitra/Staxyn): If you experience a sudden decrease or loss in hearing. Seek medical attention.
If Your Penile Erection Does Not Go Down (Vardenafil/Levitra/Staxyn): Painful erections lasting > 6 hours is known as priapism and is rare. However, if your erection lasts longer than > 4 hours, seek medical condition. Certain medical conditions such as sickle cell anemia, multiple myeloma and leukemia have been associated with a higher risk of priapism.
If You Experience Vision Loss (Vardenafil/Levitra/Staxyn): Vision loss is rare but may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). Please seek medical attention immediately for any sudden loss of vision in one or both eyes. Risk factors for NAION include coronary artery disease (CAD), diabetes, hypertension, hyperlipidemia, smoking and > 50 years of age.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Well tolerated, most side effects are transient and mild to moderate in nature. However, adverse effects such as flushing, diarrhea, myalgia and visual disturbances can increase with doses greater than 100mg every 24 hours. The most common side effects include:
Cardiovascular: Flushing (8% to 11%)
Central Nervous System: Headache (14% to 15%)
Gastrointestinal: Dyspepsia (3% to 4%), nausea (2%)
Respiratory: Rhinitis (9%), flu-like symptoms (3%), nasal congestion (3%), sinusitis
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