What is this medication?
Antineoplastic Agent, BCR-ABL Tyrosine Kinase Inhibitor
Dasatinib, Sprycel is indicated for treatment of lymphoblastic leukemia, myeloid leukemia
How does this medication work?
Dasatinib, Sprycel is a BCR-ABL tyrosine kinase inhibitor that targets most imatinib-resistant BCR-ABL mutations (except the T315I and F317V mutants) by distinctly binding to active and inactive ABL-kinase. Kinase inhibition halts proliferation of leukemia cells.
How should I take this medication?
Oral: 140mg once daily.
How to Take: Take once daily with or without food. Swallow whole; do not break, cut, crush, or chew tablets. Take with a meal if GI upset occurs. Do not administer proton pump inhibitors and H2 blockers concomitantly with Dasatinib, Sprycel.
What should I watch for while using this medication?
Before starting Dasatinib, Sprycel make sure your physician is aware of any allergies or medications you currently take. Dasatinib, Sprycel has been associated with bone marrow suppression (i.e. thrombocytopenia, neutropenia, anemia), cardiovascular disease (i.e. ischemic events, cardiac fluid retention, conduction abnormalities), dermatologic toxicity, fluid retention, hemorrhage, pulmonary arterial hypertension, QT prolongation and tumor lysis syndrome.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Facial edema, peripheral edema, headache, fatigue, pain, skin rash, pruritis, fluid retention, diarrhea, nausea, vomiting, abdominal pain, hematologic disturbances, infection, pain, pleural effusion, dyspnea, fever.
Note this is not a complete list of side effects for Dasatinib, Sprycel only common ones.
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