What is this medication?
Antidiabetic Agent, Biguanide; Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
Indicated for treatment of Diabetes mellitus, Type 2.
“Alert: US Warning
Metformin has been reported to cause lactic acidosis resulting in death, hypothermia, hypotension, and resistant bradyarrhythmias. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. If metformin-associated lactic acidosis is suspected, discontinue Segluromet and use general supportive measures in a hospital setting. Prompt hemodialysis is recommended.
How does this medication work?
Segluromet is a combination drug of metformin and ertugliflozin.
Metformin: Decreases hepatic glucose production, decreasing intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilization).
Ertugliflozin: By inhibiting sodium-glucose cotransporter 2 (SGLT2) in the proximal renal tubules, ertugliflozin reduces reabsorption of filtered glucose from the tubular lumen and lowers the renal threshold for glucose causing an increase in urinary excretion of glucose, therefore lowering blood glucose levels.
How should I take this medication?
What should I watch for while using this medication?
Before using Metformin+Ertugliflozin, Segluromet make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Ertugliflozin (SGLT2) inhibitor has been linked to increased incidences of bone fractures, genital mycotic infections (eg. vulvovaginal mycotic infection, vulvovaginal candidiasis, vulvovaginitis, candida balanitis, balanoposthitis), hypotension, and ketoacidosis. Acute renal injury and serious urinary tract infections including urosepsis and pyelonephritis have been reported with using SGLT2 inhibitors like ertugliflozin. Metformin can cause lactic acidosis and patients who have signs/symptoms should seek medical assistance if required. Metformin+Ertugliflozin, Segluromet should be avoided in patients with unstable heart failure, hepatic and/or renal impairment.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Genitourinary fungal infection, headache, hypovolemia, hypoglycemia, increased thirst, weight loss, severe hypoglycemia, increased urine output, vulvovaginal pruritus, back pain, renal insufficiency, nasopharyngitis, diarrhea, flatulence, nausea, vomiting, chest discomfort, flushing, palpitations, diaphoresis, nail disease, cyanocobalamin deficiency, abdominal distention, abdominal distress, abdominal pain, abnormal stools, dyspepsia, heartburn, chills, dizziness, headache, asthenia, myalgia, dyspnea, flu-like symptoms, upper respiratory tract infection
Note this is not a complete list of side effects, only the most common.
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