What is this medication?
Antirheumatic, Disease Modifying; Gastrointestinal Agent; Immunosuppressant Agent; Monoclonal Antibody; Tumor Necrosis Factor (TNF) Blocking Agent
Indicated for treatment of ankylosing spondylitis, crohn disease, ulcerative colitis, plaque psoriasis, juvenile idiopathic arthritis, rheumatoid arthritis, psoriatic arthritis.
“Alert: Black Box Warning
Patients treated with Infliximab are at an increased risk of developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants, such as methotrexate or corticosteroids.
Discontinue Infliximab if a patient develops a serious infection or sepsis.
Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with tumor necrosis factor (TNF) blockers, including Infliximab.”
How does this medication work?
Bevacizumab is a recombinant, humanized monoclonal antibody which bind and neutralizes vascular endothelial growth factor (VEGF) which prevents the proliferation and formation of new blood vessels. The inhibition of microvascular growth is believed to retards cancerous growth, however it also been effective in treating tendinopathy. Intratendinous injection of Bevacizumab has been shown to accelerate tendon healing in the early stages of tendinosis.
How should I take this medication?
Intravenous - 5mg/kg at 0, 2 and 6 weeks
Intravenous - 5mg/kg every 8 weeks.
How to Take: An infusion will be administered at an infusion center and should begin within 3 hours of reconstitution and dilution. Infuse over at least 2 hours, although use of shortened infusion duration has been utilized in patients previously tolerating at least four 2-hour infusions.
What should I watch for while using this medication?
Before starting Infliximab, Inflectra, Remicade, Renflexis make sure your physician is aware of any allergies or medications you currently take, you may be at an increased risk of developing another autoimmune disorder, hematologic disorder, heart failure, cancer, tuberculosis or experiencing a hepatic reaction.
What if I miss a dose?
If you miss an appointment for an injection, call your doctor’s office or clinic right away to reschedule. Your doctor can also help readjust your infusion schedule for future doses, if necessary.
How should I store this medication?
Store unopened vials in a refrigerator at 2°C to 8°C (36°F to 46°F). If needed, unopened vials may be stored at room temperatures up to a maximum of 30ºC (86°F) for a single period of up to 6 months but not exceeding the original expiration date.
What are the possible side effects of using this medication?
Headache, abdominal pain, nausea, anemia, elevated liver enzymes, antibody development, increased ANA titer and antibody development, local injection site pain and irritation, respiratory tract infection, sinusitis, cough, and pharyngitis.
Note this is not a complete list of side effects for Infliximab, Inflectra/Remicade/Renflexis only common ones.
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