What is this medication?
Letermovir, Prevymis is indicated for treatment of cytomegalovirus (CMV) prophylaxis
How does this medication work?
Prevymis prevents cytomegalovirus (CMV) infection and disease in adults who have received an allogenic hematopoietic stem cell (bone marrow) transplant by targeting the CMV DNA terminase complex (pUL51, pUL56, pUL89), which is required for viral DNA processing and packaging. Prevymis affects production of genome unit lengths and alters virion maturation.
How should I take this medication?
Usual (Oral): Oral: 480 mg once daily beginning between day 0 and day 28 postallogeneic HSCT for CMV-seropositive recipients; continue through day 100 post-transplantation.
Usual (IV): 480 mg once daily beginning between day 0 and day 28 postallogeneic HSCT for CMV-seropositive recipients; continue through day 100 post-transplantation.
How to Take:
Oral: Administer with or without food; swallow tablet whole.
IV: Infuse as an IV infusion over 1 hour through a peripheral or central venous catheter; do not administer as IV bolus. Infuse via a 0.2- or 0.22-micron polyethersulfone in-line filter. Not compatible with polyurethane-containing IV administration sets; refer to manufacturer’s labeling for compatible infusion sets.
What should I watch for while using this medication?
Before using Letermovir, Prevymis make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Letermovir, Prevymis should not be used in patients with severe hepatic impairment. Use Letermovir, Prevymis cautiously in patients with renal impairment.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Peripheral edema, headache, fatigue, nausea, diarrhea, vomiting, abdominal pain, decreased platelet count, cough
Note this is not a complete list of side effects, only the most common.
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