What is this medication?
Angiotensin-converting enzyme (ACE) inhibitor, calcium channel blocker
Brand Name US: Prestalia
Canadian Equivalent: Viacoram
Perindopril+Amlodipine is indicated for treatment of hypertension.
“Alert: US Warning
Drugs that act directly on the renin-angiotensin system such as Perindopril can cause fetal toxicity resulting in harm and potentially death. Discontinue perindopril and amlodipine as soon as pregnancy is confirmed.”
How does this medication work?
Amlodipine is a calcium channel blocker that causes peripheral vascular smooth muscle relaxation and reduces myocardial contractility which lowers blood pressure.
Perindopril prevents the conversion of angiotensin I to angiotensin II, a vasoconstrictor. As well, perindopril reduces aldosterone secretion.
How should I take this medication?
Usual (Oral): Initial dose 1 tablet (3.5mg perindopril/2.5mg amlodipine) once daily. Adjust dose according to response; maximum daily dose of 14mg perindopril/10mg amlodipine.
How to Take: Take with or without food.
What should I watch for while using this medication?
Before starting Amlodipine+Perindopril, Prestalia/Viacoram make sure your physician is aware of any allergies or medications you currently take, and current medical conditions. Amlodipine increases the risk of angina in patients with severe coronary artery disease when not used concurrently with a beta-blocker. Angioedema, cholestatic jaundice, dry cough, hyperkalemia, hypotension and a deterioration in renal function can occur when using ACE inhibitors such as perindopril. Amlodipine+Perindopril, Prestalia/Viacoram should be used with caution in patients with aortic and renal artery stenosis, pre-existing cardiovascular disease, collagen vascular disease, hepatic and renal impairment.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
1% to 10%:
Cardiovascular: Peripheral edema (2% to 7%), exacerbation of angina pectoris, hypotension, myocardial infarction (more likely in patients with severe obstructive coronary artery disease)
Central nervous system: Dizziness (3%), headache (3%)
Dermatologic: Skin rash
Endocrine & metabolic: Hyperkalemia (2%)
Gastrointestinal: Diarrhea, nausea
Renal: Renal insufficiency
Respiratory: Cough (3%)
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