What is this medication?
Antiemetic; First Generation (Typical) Antipsychotic; Phenothiazine Derivative
Perphenazine, Trilafon is indicated for management of nausea/vomiting, and schizophrenia.
“ALERT: US Boxed Warning
Increased mortality in elderly patients with dementia-related psychosis:
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 and 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was approximately 4.5% compared with a rate of approximately 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Perphenazine is not approved for the treatment of patients with dementia-related psychosis.”
How does this medication work?
Perphenazine, Trilafon is a piperazine phenothiazine antipsychotic which blocks dopamine, subtype 2 (D2), receptors in mesolimbocortical and nigrostriatal areas of the brain.
How should I take this medication?
Oral: Initial: 8 to 32 mg/day in divided doses; titrate based on response and tolerability.
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature.
You Need to Avoid: Do not stop this medication suddenly, make sure your physician is aware and can create a tapering schedule so you can come off slowly and prevent any withdrawal symptoms.
What should I watch for while using this medication?
Before starting Perphenazine, Trilafon make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, dementia, depression, hepatic impairment, renal impairment, respiratory disease, a seizure disorder, are pregnant, or breastfeeding. Perphenazine, Trilafon use has been associated with rare but serious adverse events such as altered cardiac conduction, anticholinergic effects, antiemetic effect masking other toxicity, blood dyscrasias, CNS depression, esophageal dysmotility/aspiration, extrapyramidal symptoms, increased risk of falls, hyperprolactinemia, neuroleptic malignant syndrome, ocular effects, orthostatic hypotension, photosensitivity, and temperature regulation issues.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Bradycardia, ECG changes, hypertension, hypotension, orthostatic hypotension, peripheral edema, tachycardia, bizarre dream, catatonic-like state, cerebral edema, confusion (nocturnal), disruption of body temperature regulation, dizziness, drowsiness, extrapyramidal reaction (akathisia, dystonia, Parkinsonian-like syndrome, tardive dyskinesia), headache, hyperactivity, hyperpyrexia, insomnia, lethargy, myasthenia, neuroleptic malignant syndrome (NMS), paradoxical excitation, paranoia, restlessness, seizure, diaphoresis, pallor, skin discoloration (blue-gray), skin photosensitivity, amenorrhea, change in libido, galactorrhea, glycosuria, gynecomastia, hyperglycemia, hypoglycemia, menstrual disease, SIADH (syndrome of inappropriate antidiuretic hormone secretion), weight gain, anorexia, constipation, diarrhea, fecal impaction, increased appetite, nausea, obstipation, paralytic ileus, salivation, vomiting, xerostomia, bladder paralysis, breast hypertrophy, ejaculatory disorder, lactation, urinary incontinence, urinary retention, agranulocytosis, eosinophilia, hemolytic anemia, immune thrombocytopenia (formerly known as immune thrombocytopenic purpura), leukopenia, pancytopenia, hepatotoxicity, jaundice, hypersensitivity reaction, lupus-like syndrome, blurred vision, corneal changes, epithelial keratopathy, glaucoma, lens disease, miosis, mydriasis, photophobia, retinitis pigmentosa, polyuria, nasal congestion
Note the frequency of side effects have not been defined.
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