OTEZLA (Apremilast)

OTEZLA (Apremilast)

Vendor
AMGEN
Regular price
$1,399.99 USD
Sale price
$1,399.99 USD
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Shipped from Canada.

prescription

What is this medication?

Apremilast, Otezla
Phosphodiesterase-4 Enzyme Inhibitor

Officially indicated for the treatment of Behcet disease, psoriasis, and psoriatic arthritis.

How does this medication work?

Apremilast, Otezla is an inhibitor of phosphodiesterase 4 (PDE4) and works intracellularly to modulate a network of pro-inflammatory and anti-inflammatory mediators.  Phosphodiesterase 4 inhibition elevates intracellular cAMP levels, thereby reducing the inflammatory response by modulating the expression of tumor necrosis factor-α (TNF-α), interleukin-23 (IL-23), IL-17 and IL-10.

How should I take this medication?

Bechet Disease
Oral: Take 10 mg in the morning on day 1. Titrate upward by additional 10 mg per day on days 2 to 5 as follows: Day 2: 10 mg twice daily; Day 3: 10 mg in the morning and 20 mg in the evening; Day 4: 20 mg twice daily; Day 5: 20 mg in the morning and 30 mg in the evening. Maintenance dose: 30 mg twice daily starting on day 6.

Psoriasis
Oral: Take 10 mg in the morning on day 1. Titrate upward by additional 10 mg per day on days 2 to 5 as follows: Day 2: 10 mg twice daily; Day 3: 10 mg in the morning and 20 mg in the evening; Day 4: 20 mg twice daily; Day 5: 20 mg in the morning and 30 mg in the evening. Maintenance dose: 30 mg twice daily starting on day 6.

Psoriatic Arthritis
Oral: Take 10 mg in the morning on day 1. Titrate upward by additional 10 mg per day on days 2 to 5 as follows: Day 2: 10 mg twice daily; Day 3: 10 mg in the morning and 20 mg in the evening; Day 4: 20 mg twice daily; Day 5: 20 mg in the morning and 30 mg in the evening. Maintenance dose: 30 mg twice daily starting on day 6.

How to Use: Can be taken with/without food.  Do not crush, chew, or split the tablets.

What should I watch for while using this medication?

Use with caution in patients (≥65 years) and patients taking medications that may lead to volume depletion or hypotension

Use with caution in patients with a history of depression and/or suicidal thoughts /behavior

May cause weight loss, monitor weight regularly. Discontinuation of therapy should be considered with unexplained or significant weight loss

Use with caution in patients with rental impairment

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible.  However, if it is almost time for your next dose, take only that scheduled dose.  Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times.  Store at room temperature, 59 to 86° F (15 to 30° C).  Protect from light.  Keep the container tightly closed.  Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication?

The frequency of adverse reactions has been reported as the following:

Central Nervous System: Tension headache (7%), headache (6%), fatigue (3%), depression (2%), insomnia (2%), migraine (2%), paresthesia (<2%)

Dermatologic: Skin rash (<2%), folliculitis (1%)

Endocrine & Metabolic: Weight loss (5% to 10% of body weight: 10% to 12%; ≥10% of body weight: 2%)

Gastrointestinal: Diarrhea (18%), nausea (17%), vomiting (4%), decreased appetite (3%), dyspepsia (3%), abdominal distress (2%), abdominal pain (2%), frequent bowel movements (2%), upper abdominal pain (2%), abdominal distention (<2%), gastroesophageal reflux disease (<2%)

Hypersensitivity: Hypersensitivity reaction (<2%)

Infection: Influenza (<2%), tooth abscess (1%)

Neuromuscular & Skeletal: Back pain (2%), arthralgia (<2%), muscle spasm (<2%), myalgia (<2%)

Respiratory: Upper respiratory tract infection (8%), nasopharyngitis (7%), sinusitis (2%), bronchitis (<2%), cough (<2%), pharyngitis (<2%), rhinitis (<2%), sinus headache (<2%)