What is this medication?
Antirheumatic, Disease Modifying; Selective T-Cell Costimulation Blocker
Indicated for treatment of juvenile idiopathic arthritis, rheumatoid arthritis, psoriatic arthritis.
How does this medication work?
Abatacept, Orencia is a selective costimulation modulator, inhibits T cell (T lymphocyte) activation by binding to CD80 and CD86, thereby blocking interaction with CD28. This interaction provides a costimulatory signal necessary for full activation of T lymphocytes.
How should I take this medication?
Intravenous - Dosing is according to body weight. Following the initial IV infusion (using the weight-based dosing), repeat IV infusion (using the same weight-based dosing) at 2 weeks and 4 weeks after the initial infusion, and every 4 weeks thereafter.
Subcutaneous - Inject 125mg subcutaneously once weekly.
How to Take: Follow instructions provided by physician/pharmacy label, allow prefilled syringe and autoinjector to warm to room temperature (for 30 to 60 minutes and 30 minutes, respectively) prior to administration. Inject full amount into the front of the thigh (preferred), abdomen (except for 2-inch area around the navel), or the outer area of the upper arms (if administered by a caregiver). Rotate injection sites (≥1 inch apart); do not administer into tender, bruised, red, or hard skin.
What should I watch for while using this medication?
Before starting Abatacept, Orencia make sure your physician is aware of any allergies or medications you currently take, you may be at an increased risk of infection and malignancy and should be used in patients who are immunocompromised (i.e. COPD).
What if I miss a dose?
If you miss a scheduled dose, talk to your doctor to find out when you should take your next dose. Try your best to take medication as scheduled, and set reminders on days that you are scheduled to take Orencia.
How should I store this medication?
Store in the refrigerator at 36 °F to 46 °F (2 °C to 8 °C) until you are ready to use. Be sure to keep in the original package and out of the light. DO NOT freeze. Safely throw away medicine that is out of date or no longer needed.
What are the possible side effects of using this medication?
Headache, nausea, antibody development, infection, influenza, bronchitis, sinusitis, nasopharyngitis.
Note this is not a complete list of side effects for Abatacept, Orencia only common ones.
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