What is this medication?
Antirheumatic, Janus Associated Kinase Inhibtor
Baricitinib, Olumiant is indicated for treatment of rheumatoid arthritis.
“Alert: Black Box Warning
Patients treated with Baricitinib, Olumiant are at risk for developing serious infections that may lead to hospitalization or death. Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. The risks and benefits of treatment with Baricitinib, Olumiant should be carefully considered prior to initiating therapy in patients with chronic or recurrent infection. Patients should be closely monitored for the development of signs and symptoms of infection during and after treatment with Baricitinib, Olumiant including the possible development of tuberculosis in patients who tested negative for latent tuberculosis infection prior to initiating therapy.
Lymphoma and other malignancies have been observed in patients treated with Baricitinib, Olumiant.
Thrombosis, including deep venous thrombosis and pulmonary embolism, has been observed at an increased incidence in patients treated with Baricitinib, Olumiant compared to placebo. In addition, there were cases of arterial thrombosis. Many of these adverse events were serious and some resulted in death. Patients with symptoms of thrombosis should be promptly evaluated.”
How does this medication work?
Baricitinib, Olumiant modulates cytokine signaling by targeting receptors associated with JAK1 and JAK2 pathways believed to important in the pathogenesis of rheumatoid arthritis.
How should I take this medication?
Oral: 2mg once daily.
Note: Baricitinib, Olumiant should not be used in combination with biologic disease-modifying antirheumatic drugs (DMARDs) or with strong immunosuppressants such as azathioprine or cyclosporine. Do not initiate therapy in patients with an absolute lymphocyte count <500 cells/mm3, absolute neutrophil count <1,000 cells/mm3, or hemoglobin <8 g/dL.
How to Take: Take with or without food. For patients unable to swallow tablets whole, the tablet may be chewed; ensure entire dose is swallowed.
What should I watch for while using this medication?
Before starting Baricitinib, Olumiant make sure your physician is aware of any allergies or medications you currently take. Baricitinib, Olumiant must be used with caution in patients at increased risk of GI perforation, currently taking immunosuppressive agents because of their higher risk of getting tuberculosis, invasive fungal candidiasis and pneumocystosis and bacterial, viral or other opportunistic infections. Baricitinib, Olumiant has been associated with lipid abnormalities, thrombosis and malignancies and as a result patients require careful monitoring.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Infection, nausea, elevated liver enzymes.
Note this is not a complete list of side effects for Baricitinib, Olumiant only common ones.
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