What is this medication?
Antineoplastic Agent, Tyrosine Kinase Inhibitor; Vascular Endothelial Growth Factor (VEGF) Inhibitor
Sorafenib, Nexavar is indicated for treatment of hepatocellular carcinoma; Renal cell carcinoma, advanced; Thyroid carcinoma, differentiated.
How does this medication work?
Sorafenib, Nexavar is a multikinase inhibitor that inhibits tumor growth and angiogenesis by inhibiting intracellular Raf kinases (CRAF, BRAF, and mutant BRAF), and cell surface kinase receptors (VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-beta, cKIT, FLT-3, RET, and RET/PTC)
How should I take this medication?
Oral: 400 mg twice daily until no longer clinically benefiting or until unacceptable toxicity occurs
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature. Administer without food (at least 1 hour before or 2 hours after a meal).
You Need to Avoid: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber. Temporarily withhold sorafenib for at least 10 days prior to elective surgery; do not administer sorafenib for at least 2 weeks following major surgery and until adequate wound healing.
What should I watch for while using this medication?
Before starting Sorafenib, Nexavar make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding. Sorafenib, Nexavar use has been associated with rare but serious adverse events such as bleeding, cardiovascular events, dermatologic toxicity, GI perforation, hepatotoxicity, hypertension, QT prolongation, thyroid impairment, and wound healing complications.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Hypertension, alopecia, palmar-plantar erythrodysesthesia, pruritus, skin rash, xeroderma, hypoalbuminemia, hypocalcemia, hypophosphatemia, increased amylase, increased thyroid stimulating hormone level, weight loss, abdominal pain, anorexia, constipation, decreased appetite, diarrhea, gastrointestinal hemorrhage, increased serum lipase, nausea, stomatitis, vomiting, anemia, hemorrhage, increased INR, leukopenia, lymphocytopenia, neutropenia, thrombocytopenia, hepatic insufficiency, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, infection, fatigue, headache, mouth pain, pain (including tumor pain), peripheral sensory neuropathy, voice disorder, asthenia, limb pain, ostealgia, dyspnea, respiratory tract hemorrhage, fever
Note this is not a complete list of side effects, only the most common.
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