What is this medication?
Antibiotic, Tetracycline Derivative
Officially indicated as an antibiotic for various bacterial infections. It is sometimes used off-label for neuroinflammation.
How does this medication work?
Minocycline inhibits protein synthesis by binding with the 30S and possibly the 50S ribosomal subunit(s) of susceptible bacteria; may also cause alterations in the cytoplasmic membrane. Minocycline also inhibits microglial activation and pro-inflammatory cytokine release. Minocycline has been shown to have neuroimmune modulatory properties that promotes remyelination and improves cognition and memory following injury.
How should I take this medication?
Oral: Take as directed by medical doctor; never exceed the maximum recommended daily dose.
How to Use: Take minocycline with food to reduce gastrointestinal symptoms. Take with a full glass of water and do not lie down for at least 30 minutes after taking to reduce the risk of esophageal irritation and ulceration.
Is Minocycline Safe to Use During Pregnancy: Minocycline has in rare cases been linked to congenital anomalies. Due to a limited amount of information, a causal relationship has not been established. However, tetracyclines as a class should generally be considered a second-line antibiotic in pregnant women and their use should be avoided.
What should I watch for while using this medication?
Can cause esophagitis and ulcerations
Discontinue use in patients who experience a hypersensitivity syndrome, renal impairment, intracranial hypertension
Can cause photosensitivity and tissue hyperpigmentation
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Well tolerated, most side effects are transient and mild to moderate in nature. The most common side effects include:
Dermatologic: Pruritus (5%), urticaria (2%)
Nervous system: Dizziness (9%), fatigue (9%), malaise (4%), drowsiness (2%)
Neuromuscular & skeletal: Arthralgia (1%)
Otic: Tinnitus (2%)
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