What is this medication?
Oral, IM (acetate or succinate), and IV (succinate only): Anti-inflammatory or immunosuppressant agent in the treatment of a variety of diseases, including those of hematologic (i.e. immune thrombocytopenia, warm autoimmune hemolytic anemia), allergic, gastrointestinal (i.e. Crohn disease, ulcerative colitis), inflammatory, neoplastic, neurologic (i.e. multiple sclerosis), rheumatic (i.e. antineutrophil cytoplasmic antibody-associated vasculitis, dermatomyositis/polymyositis, giant-cell arteritis, gout (acute flare), giant cell arteritis, mixed cryoglobulinemia syndrome, polyarteritis nodosa, rheumatoid arthritis, systemic lupus erythematosus), and/or autoimmune origin.
Intra-articular or soft tissue administration (acetate only): Gout (acute flare), acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, and/or synovitis of osteoarthritis.
Intralesional administration (acetate only): Alopecia areata; discoid lupus erythematosus; keloids; localized hypertrophic, infiltrated, inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis), and psoriatic plaques; and necrobiosis lipoidica diabeticorum. May be useful in cystic tumor of an aponeurosis or tendon (ganglia).
How does this medication work?
Methylprednisolone, Depo-Medrol/Medrol/Solu-Medrol binds and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This results in a significant decrease in inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.
How should I take this medication?
Oral: 16mg to 64mg once daily or in divided doses.
What should I watch for while using this medication?
Before starting Methylprednisolone, Depo-Medrol/Medrol/Solu-Medrol make sure your physician is aware of any allergies or medications you currently take. Methylprednisolone, Depo-Medrol/Medrol/Solu-Medrol can increase your risk of experiencing adrenal suppression, hepatic injury, immunosuppression, Kaposi sarcoma, myopathy, psychiatric disturbances. You should use Methylprednisolone, Depo-Medrol/Medrol/Solu-Medrol with caution in patients who suffer from cardiovascular disease, diabetes, gastrointestinal disease, hepatic impairment, myasthenia gravis, ocular disease, osteoporosis, seizures, septic shock, scleroderma and thyroid disease.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
The frequency of incidence of side effects has not been reported but can include the following: bradycardia, cardiac failure, cardiac arrhythmia, edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis, depression, emotional lability, euphoria, headache, insomnia, malaise, meningitis, neuritis, neuropathy paraplegia, vertigo, acne, alopecia, ecchymoses, epidermal thinning, erythema, adrenal suppression, Cushing syndrome, insulin resistance, abdominal distension, bladder dysfunction, tendon rupture, myopathy, intraocular pressure, pulmonary edema, rhinitis.
Note this is not a complete list of side effects for Methylprednisolone, Depo-Medrol/Medrol/Solu-Medrol only common ones.
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