What is this medication?
Sphingosine 1-Phosphate (S1P) Receptor Modulator
Indicated for management of multiple sclerosis.
How does this medication work?
Siponimod, Mayzent is a sphingosine-1-phosphate (S1P) receptor modulator that binds to sphingosine 1-phosphate receptors 1 and 5. This inhibits lymphocyte release from lymph nodes, thereby decreasing the number of lymphocytes available to the CNS which reduces central inflammation.
How should I take this medication?
Oral: CYP2C9 Genotype *1/*1, *1/*2, or *2/*2: 0.25 mg once daily on Days 1 and 2, then 0.5 mg once daily on Day 3, then 0.75 mg once daily on Day 4, then 1.25 mg once daily on Day 5 then maintain on 2mg once daily Day 6 and on.
CYP2C9 Genotype *1/*3 or *2/*3: 0.25 mg once daily on Days 1 and 2, then 0.5 mg once daily on Day 3, then 0.75 mg once daily on Day 4 then maintain on 1mg once daily Day 5 and on.
How to Take: Administer with or without food. Swallow tablets whole; do not chew, crush, or split. Cases of rebound syndrome (clinical and radiological signs of severe exacerbation beyond what was expected) have been reported with discontinuation of another sphingosine 1-phosphate receptor modulator. Monitor for development of severe increase in disability following discontinuation and begin appropriate treatment as needed. Avoid immunization with live attenuated vaccines during and for 4 weeks after treatment. Vaccines may not be as effective if administered during therapy; discontinuation of treatment 1 week before and 4 weeks following a planned vaccination is recommended.
You Need to Avoid: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber. Avoid missing dosages. If a dose is missed for more than 24 hours during the initial titration regimen, reinitiate with Day 1 of the titration regimen. If treatment with siponimod is interrupted for 4 or more consecutive daily doses after completion of initial titration, reinitiate treatment with Day 1 of the titration regimen, including first-dose monitoring when appropriate.
What should I watch for while using this medication?
Before starting Siponimod, Mayzent make sure your physician is aware of any allergies or medications you currently take, if you have cardiovascular disease, hepatic impairment, CYP2C9*3/*3 genotype, if you are immunocompromised, have an active infection, active malignancy, are pregnant, or breastfeeding. Siponimod, Mayzent use has been associated with rare but serious adverse events such as atrioventricular conduction delays, bradycardia, hepatic effects, hypertension, increased risk of infection, macular edema, malignancy, neurotoxicity, progressive multifocal leukoencephalopathy, QT prolongation, and reduced respiratory function.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store unopened containers in a refrigerator between 2°C to 8°C (36°F to 46°F); may be stored at 20°C to 25°C (68°F to 77°F) for ≤3 months after dispensing to the patient. Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Hypertension, headache, falling, increased serum transaminases, peripheral edema, bradycardia, first degree atrioventricular block, dizziness, nausea, diarrhea, increased serum bilirubin, increased serum alanine aminotransferase, limb pain
Note this is not a complete list of side effects, only the most common.
- Choosing a selection results in a full page refresh.
- Press the space key then arrow keys to make a selection.