What is this medication?
Antineoplastic Agent, PARP Inhibitor
Olaparib, Lynparza is indicated for treatment of breast cancer, metastatic; ovarian cancer, advanced; pancreatic cancer, metastatic; prostate cancer, metastatic, castration-resistant.
How does this medication work?
Olaparib, Lynparza is a poly (ADP-ribose) polymerase (PARP) enzyme inhibitor, including PARP1, PARP2, and PARP3. PARP enzymes are involved in DNA transcription, cell cycle regulation, and DNA repair.
How should I take this medication?
Oral: 300-400mg twice daily
How to Take: Administer approximately every 12 hours with or without food. Swallow tablets whole; do not chew, crush, dissolve, or divide tablet. Swallow capsules whole; do not chew, dissolve, or open capsule; do not administer if capsules appear deformed or show evidence of leakage. Olaparib is available in tablets and (in some regions) capsules. Due to differences in dosing and bioavailability, do not substitute capsules for tablets (or vice versa) on a mg-per-mg basis.
You Need to Avoid: Avoid grapefruit, grapefruit juice, Seville oranges, or Seville orange juice as they may increase olaparib plasma concentrations.
What should I watch for while using this medication?
Before starting Olaparib, Lynparza make sure your physician is aware of any allergies or medications you currently take, if you have renal impairment, are pregnant, or breastfeeding. Olaparib, Lynparza use has been associated with rare but serious adverse events such as bone marrow suppression, GI toxicity, hypersensitivity reactions, pulmonary toxicity, and secondary malignancies.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Skin rash, hypomagnesemia, abdominal pain, constipation, decreased appetite, diarrhea, dysgeusia, dyspepsia, nausea, stomatitis, vomiting, urinary tract infection, anemia, leukopenia, neutropenia, thrombocytopenia, influenza, dizziness, fatigue, headache, arthralgia, asthenia, back pain, myalgia, increased serum creatinine, bronchitis, cough, dyspnea, nasopharyngitis, respiratory tract infection, rhinitis, sinusitis, upper respiratory tract infection
Note this is not a complete list of side effects, only the most common.
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