What is this medication?
Antineoplastic Agent; Anaplastic Lymphoma Kinase Inhibitor; Tyrosine Kinase Inhibitor
Indicated for treatment of non-small cell lung cancer.
How does this medication work?
Lorlatinib, Lorbrena is a potent reversible third generation tyrosine kinase inhibitor. It highly selectively targets ALK and ROS1, overcomes known ALK resistance mutations, and penetrates the blood brain barrier. It is effective against multiple mutant forms of the ALK enzyme. Lorlatinib also exhibits activity against TYK1, FER, FPS, TRKA, TRKB, TRKC, FAK, FAK2, and ACK.
How should I take this medication?
Oral: 100 mg once daily and continue until disease progression or unacceptable toxicity
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature. Administer with or without food at the same time each day. Swallow intact tablets whole.
You Need to Avoid: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance so avoid starting any new medications without consulting prescriber. Do not ingest tablets that are broken, cracked or otherwise not intact. If vomiting occurs, do not administer an additional dose; continue with the next scheduled dose.
What should I watch for while using this medication?
Before starting Lorlatinib, Lorbrena make sure your physician is aware of any allergies or medications you currently take, if you are pregnant, or breastfeeding. Lorlatinib, Lorbrena use has been associated with rare but serious adverse events such as bone marrow suppression, ECG changes, CNS effects (seizure, hallucinations, cognitive function, mood, suicidal ideation, speech, mental status, sleep), hepatotoxicity, hyperlipidemia, and pulmonary toxicity.
What if I miss a dose?
If a dose is missed, administer the missed dose unless it is due within 4 hours. Do not administer 2 doses to make up for a missed dose.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Edema, peripheral neuropathy, cognitive dysfunction, fatigue, mood disorder, headache, dizziness, speech disturbance, sleep disorder, skin rash, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, hypoalbuminemia, weight gain, increased amylase, hyperkalemia, hypomagnesemia, hypophosphatemia, increased serum lipase, diarrhea, nausea, constipation, vomiting, anemia, thrombocytopenia, lymphocytopenia, increased serum aspartate aminotransferase, increased serum alanine aminotransferase, increased serum alkaline phosphatase, arthralgia, myalgia, back pain, limb pain, visual disturbance, dyspnea, cough, upper respiratory tract infection, fever
Note this is not a complete list of side effects, only the most common.
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