What is this medication?
Officially indicated to treat onychomycosis, tinea capitis and other dermatologic fungal infections depending on the formulation.
How does this medication work?
Terbinafine/Lamisil is a synthetic allylamine derivative that inhibits squalene epoxidase, a key enzyme in sterol biosynthesis in fungi. This results in a deficiency in ergosterol within the fungal cell membrane and results in fungal cell death.
How should I take this medication?
Oral: Take 250mg once daily for 6 weeks (fingernail) and/or 12 weeks (toenail)
Tinea Pedis, Tinea Corporis, Tinea Cruris
Topical (Cream, Spray): Apply to the affected area once daily for 1 week.
Topical (Cream): Apply to the affected areas once to twice daily for 1 to 2 weeks.
Topical (Cream, Spray): Apply to the affected areas once to twice daily for 1 to 2 weeks.
How to Apply/Take Terbinafine, Lamisil: When administering terbinafine/Lamisil orally. You can take the tablets with/without food; for the granules take with non-acidic food and swallow the granules whole without chewing them. When applying Lamisil/Terbinafine topically, wash your hands before and after application.
What should I watch for while using this medication?
Use in caution in patients with allylamine antifungal sensitivity
Can cause taste disturbance
Hepatic failure has been reported in patients with and without pre-existing hepatic disease. Do not use in patients with hepatic impairment
Serious skin and hypersensitivity reactions including (i.e. Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, bullous dermatitis, drug reaction with eosinophilia and systemic symptoms [DRESS] syndrome) have occurred.
Smell disturbance (including loss of smell) has been reported
Thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, have been reported (some fatal)
Use with caution in patients with renal impairment
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
The frequency of side effects is not defined, dependent upon the dose, duration, and concomitant therapy.
Central Nervous System: Headache (7% to 13%)
Local Irritation: if irritation/sensitivity develops, discontinue therapy and institute appropriate
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