What is this medication?
Antineoplastic Agent; Janus Associated Kinase Inhibitor; Tyrosine Kinase Inhibitor
Indicated for treatment of acute graft-versus-host disease, myelofibrosis, polycythemia vera.
Jakavi Safety Review June 2020
Health Canada has reviewed the risk of venous thromboembolic events (VTE) and pulmonary embolism with Jakavi (ruxolitinib) and has concluded that there is a possible link between the risk of VTE and the use of Jakavi. Health Canada will work with the manufacturer for Jakavi to update the product safety information to include the risk of VTE."
How does this medication work?
Ruxolitinib is a kinase inhibitor which is selective for Janus Associated Kinases (JAKs), JAK1 and JAK2 which mediate signaling of cytokine and growth factors responsible for hematopoiesis and immune function.
How should I take this medication?
Oral: Initial: 5mg twice daily and titrate as required to a maximum dosage of 25mg twice daily
How to Take: May be administered orally with or without food.
What should I watch for while using this medication?
Before starting make sure your physician is aware of any allergies or medications you currently take, if you have liver disease, or kidney disease. Has been associated with rare but serious adverse events such as hematologic toxicity, infections, lipid abnormalities, and non melanoma skin cancer.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?Bruising, increased cholesterol, hypertriglyceridemia, diarrhea, anemia, thrombocytopenia, neutropenia, increased liver enzymes, dizziness, headache, insomnia, muscle spasm, dyspnea.
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