What is this medication?
Analgesic, Nonsteroidal Anti-inflammatory Drug (NSAID)
Indicated for acute pain, ankylosing spondylitis, bursitis, tendonitis, acute flares of gout, osteoarthritis, and rheumatoid arthritis.
“Alert: Black Box Warning
Serious cardiovascular thrombotic events:
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction (MI) and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use.
Indomethacin is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.
Serious gastrointestinal bleeding, ulceration, and perforation:
NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.”
How does this medication work?
Indomethacin, Indocin/Tivorbex reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes, which results in decreased formation of prostaglandin precursors; has antipyretic, analgesic, and anti-inflammatory properties.
How should I take this medication?
Oral (Immediate release [excluding Tivorbex]): 25 mg 2 to 3 times daily; if well tolerated, increase daily dosage by 25 or 50 mg at weekly intervals until satisfactory response or a total daily dose of 150 to 200 mg/day (maximum dose: 200 mg/day) is reached.
Oral (extended-release capsules): Initial: 75 mg once daily, may increase to 75 mg twice daily (maximum dose: 150 mg/day).
How to Take: Take with food, immediately after a meal to decrease GI adverse effects. The extended-release capsules must be swallowed whole; not crushed, chewed, or split
What should I watch for while using this medication?
Before starting Indomethacin, Indocin/Tivorbex make sure your physician is aware of any allergies and medications you currently take.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Note this is not a complete list of side effects for Indomethacin, Indocin/Tivorbex
only common ones. There have been reports of cardiovascular thrombotic events and gastrointestinal bleeding in rare cases when using Indomethacin, Indocin, Tivorbex.
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