What is this medication?
First Generation (typical) Antipsychotic
Haloperidol, Haldol is officially indicated for non-psychotic behavioral disorders, hyperactivity, schizophrenia, and tic management in Tourette’s syndrome. (may be used for other conditions not listed)
“ALERT: US Boxed Warning
Increased mortality in elderly patients with dementia-related psychosis:
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of 17 placebo-controlled trials (modal duration, 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was approximately 4.5%, compared with a rate of approximately 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Haloperidol is not approved for the treatment of patients with dementia-related psychosis.”
How does this medication work?
Haloperidol, Haldol is a butyrophenone antipsychotic that nonselectively blocks postsynaptic dopaminergic D2 receptors in the brain. The brains response to altered chemistry results in desired effects.
How should I take this medication?
0.5 to 10 mg up to four times per day to a maximum of 30 mg/day.
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature. The decanoate injectable formulation should be administered IM only and volume should not exceed 3mL. Experts recommend administering in the gluteal muscle by deep IM injection, however deltoid injection may also be acceptable. Administer orally with food or milk to decrease GI distress.
You Need to Avoid: Operating heavy machinery or driving at least until you know how the medication affects you. Do not stop this medication suddenly, make sure your physician is aware and can create a tapering schedule so you can come off slowly and prevent any withdrawal symptoms. This medication has many drug interactions so ask your pharmacist before starting any over the counter medications or supplements. Do not administer decanoate IV.
What should I watch for while using this medication?
Before starting Haloperidol, Haldol make sure your physician is aware of any allergies or medications you currently take, if you have Parkinson disease, severe CNS depression, dementia with Lewy bodies are in a significant depressive state, previous spastic diseases, cardiovascular disease, bipolar, dementia, myasthenia gravis, seizure, thyroid dysfunction. Haloperidol use has been associated with serious adverse reactions such as altered cardiac conduction, anticholinergic effects, blood dyscrasias, central nervous system depression, esophageal dysmotility/aspiration, extrapyramidal symptoms, falls, hyperprolactinemia, neuroleptic malignant syndrome, orthostatic hypotension, and temperature regulation issues.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Extrapyramidal reaction, parkinsonism, dystonia, hypertonia, drowsiness, akathisia, headache, constipation, abdominal pain, xerostomia, sialorrhea, hyperkinetic muscle activity, tremor, bradykinesia, akinesia, oculogyric crisis
Note- this is not a complete list of side effects, just the most common ones.
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