What is this medication?
Antidiabetic Agent; Sulfonylurea
Glyburide/Glibenclamide, Glynase/Diabeta is indicated for Diabetes Mellitus Type 2.
How does this medication work?
Glyburide/Glibenclamide, Glynase/Diabeta stimulates the release on insulin from insulin producing beta cells in pancreas, reduces glucose release from the liver and increases peripheral insulin sensitivity
How should I take this medication?
Oral: 1.25-20mg daily divided into one or two daily doses
Note micronized tablets such as Glynase Prestab in the US are not equivalent to standard tablets.
These are dosed 0.75-12mg daily divided into one or two daily dosages.
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day with a meal unless otherwise directed, store at room temperature. Dosages above 10mg/day (>6mg/day micronized) generally should be divided for better blood sugar control.
You Need to Avoid: If you reduce your caloric intake or are fasting then this medication may need to be reduced or held to avoid hypoglycemia. Alcohol can rarely cause a disulfiram reaction with this medication which is akin to an immediate severe “hangover” with consumption of even a small amount of alcohol. If this occurs, then avoid alcohol or speak to physician about your options.
What should I watch for while using this medication?
Before starting Glyburide/Glibenclamide, Glynase/Diabeta make sure your physician is aware of any allergies (sulfa), medications you currently take, if you have kidney disease, have had bariatric surgery, glucose-6-phosphate dehydrogenase deficiency, are in a high stress state (had surgery, trauma, infection, fever), are pregnant or breastfeeding
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Epigastric fullness, heartburn, nausea, hypersensitivity reaction (rash, itch, hives)
Note this is not a complete list of side effects, only common ones.
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