What is this medication?
Anticoagulant, Factor Xa Inhibitor
Indicated for treatment of deep vein thrombosis, pulmonary embolism, venous thromboembolism prophylaxis.
“Alert: US Warning
Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins, heparinoids, or fondaparinux and are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Monitor patients frequently for signs and symptoms of neurologic impairment. If neurologic compromise is noted, urgent treatment is necessary.”
How does this medication work?
Fondaparinux, Arixtra is a synthetic anticoagulant that causes an antithrombin III-mediated selective inhibition of factor Xa. Neutralization of factor Xa interrupts the blood coagulation cascade and inhibits thrombin formation and thrombus development.
How should I take this medication?
Usual (SubQ): 5mg to 10mg once daily
Note: Prothrombin time and activated partial thromboplastin time are insensitive measures of Arixtra activity. If unexpected changes in coagulation parameters or major bleeding occur, discontinue fondaparinux.
How to Take:
SubQ: For SubQ administration; do not administer IM. Alternate injection sites. Do not expel air bubble from syringe before injection. Administer according to recommended regimen; when used for DVT prophylaxis, early initiation (before 6 hours after orthopedic surgery) has been associated with increased bleeding.
What should I watch for while using this medication?
Before using Fondaparinux, Arixtra make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Monitor patient closely for signs or symptoms of bleeding. Fondaparinux, Arixtra has been reported to cause thrombocytopenia with thrombosis. Use Fondaparinux, Arixtra with caution in patients with hepatic and renal impairment because of the increased risk of bleeding.
What if I miss a dose?
If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses to make up for the missed dose.
How should I store this medication?
Stored below 25°C. Do not freeze. If Arixtra is added to a 0.9% saline minibag it should be infused immediately, but can be stored between 15-30°C for up to 24 hours. Minibags are typically composed of a variety of polymers including PVC, polyethylene, polypropylene, or styrene-ethylenebutadiene, individually or in combination.
What are the possible side effects of using this medication?
Anemia, hypotension, confusion, dizziness, insomnia, increased wound secretion, skin blister, hypokalemia, hematoma, major hemorrhage, minor hemorrhage, postoperative hemorrhage, purpura, thrombocytopenia, increased Serum ALT, increased Serum AST
Note this is not a complete list of side effects, only the most common.
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