What is this medication?
Deferasirox, Exjade/Jadenu is indicated for treatment of chronic iron overload.
“Alert: Black Box Warning
Deferasirox, Exjade/Jadenu can cause acute renal failure and death, particularly in patients with comorbidities and those who are in the advanced stages of their hematologic disorders. Deferasirox, Exjade/Jadenu requires an evaluation of renal function prior and during therapy to assess for signs of acute renal failure.
Deferasirox, Exjade/Jadenu can cause hepatic injury, including hepatic failure and death. Measure serum transaminases and bilirubin in all patients prior to initiating treatment, every 2 weeks during the first month, and at least monthly thereafter. Avoid use of deferasirox in patients with severe (Child-Pugh class C) hepatic impairment and reduce the dose in patients with moderate (Child-Pugh class B) hepatic impairment.
Deferasirox, Exjade/Jadenu can cause GI hemorrhages, which may be fatal, especially in elderly patients who have advanced hematologic malignancies and/or low platelet counts. Monitor patients and discontinue Deferasirox, Exjade/Jaden for suspected GI ulceration or hemorrhage.”
How does this medication work?
Deferasirox, Exjade/Jadenu is an iron chelating agent that selectively binds iron, forming a complex that is excreted primarily through the feces.
How should I take this medication?
Oral (Exjade): 20mg/kg once daily; adjust dosage based on serum ferritin trends.
Oral (Jadenu): 14mg/kg once daily; adjust dosage based on serum ferritin trends.
How to Take:
Oral (Exjade): for tablets, do not chew or swallow tablets whole. Completely disperse tablets in water, orange juice, or apple juice (use 105 mL for total doses <1 g; 210 mL for doses ≥1 g); stir to form a fine suspension and drink entire contents. Rinse remaining residue with more fluid; drink. Avoid dispersion of tablets in milk (due to slowed dissolution) or carbonated drinks (due to foaming). Administer at same time each day on an empty stomach, at least 30 minutes before food.
Oral (Jadenu): for granules, take on an empty stomach or with a light meal at the same time each day. For the tablets, swallow with water at the same time each day. Take on an empty stomach or with a light meal. The tablets can be crushed and mixed with soft food if needed.
What should I watch for while using this medication?
Before starting Deferasirox, Exjade/Jadenu make sure your physician is aware of any allergies or medications you currently take. Decreased hearing and high-frequency hearing loss have been reported with using Deferasirox, Exjade/Jadenu. Bone marrow suppression including agranulocytosis, neutropenia, thrombocytopenia, and worsening anemia have been reported (some fatal) have been reported to occur with using Deferasirox, Exjade/Jadenu. Deferasirox, Exjade/Jadenu can also cause dermatologic toxicity, gastrointestinal reactions, hepatic failure, ocular disturbances and in some cases even renal failure.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Skin rash, abdominal pain, nausea, vomiting, diarrhea, proteinuria.
Note this is not a complete list of side effects for Deferasirox, Exjade/Jadenu only common ones.
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