What is this medication?
Rivastigmine, Exelon is officially indicated for Alzheimer’s dementia and Parkinson disease dementia. It is also prescribed off-label for vascular dementia and dementia with Lewy bodies. (may be used for conditions not listed)
How does this medication work?
A deficiency in cortical acetylcholine is thought to be a cause of some of the symptoms of both Parkinson’s induced dementia and Alzheimer’s disease. Rivastigmine reversibly inhibits acetylcholinesterase thereby preventing the breakdown of acetylcholine via hydrolysis in the central nervous system.
How should I take this medication?
Oral: 1.5-6mg twice daily spaced approximately 12 hours apart
How to Take: Oral: Follow instructions provided by physician/pharmacy label, swallow whole with food, take consistently at same times each day unless otherwise directed, store at room temperature.
What should I watch for while using this medication?
Before starting Rivastigmine, Exelon make sure your physician is aware of any allergies or medications you currently take, if you have peptic ulcer disease, respiratory disease, a seizure disorder, a urinary tract obstruction, or are pregnant or breastfeeding. Let your physician know if you are a smoker as nicotine can increase metabolism of rivastigmine by 23%. Patients weighing less than 50kg or more than 100kg will have altered systemic absorption and dosage may be adjusted.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Central nervous system: Dizziness (oral: 6% to 21%; transdermal: ≤6%), headache (oral: 4% to 17%; transdermal ≤4%), agitation (transdermal: 1% to 14%), falling (6% to 12%)
Endocrine & metabolic: Weight loss (3% to 26%)
Gastrointestinal: Nausea (oral: 17% to 47%; transdermal: 2% to 10%), vomiting (oral: 13% to 31%; transdermal: 3% to 9%), diarrhea (oral: 5% to 19%; transdermal: ≤7%), anorexia (oral: ≤17%; transdermal: ≤3%), abdominal pain (oral: 13%; transdermal: 2%)
Local: Application site erythema (transdermal: 1% to 13%)
Neuromuscular & skeletal: Tremor (oral: 4% to 23%; transdermal: 7%)
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