What is this medication?
Topical Phosphodiesterase-4-Enzyme Inhibitor
Eucrisa/Crisaborole is an inhibitor of phosphodiesterase 4 (PDE4) and works intracellularly to modulate a network of pro-inflammatory and anti-inflammatory mediators. Phosphodiesterase 4 inhibition elevates intracellular cAMP levels, thereby reducing the inflammatory response by modulating the expression of tumor necrosis factor-α (TNF-α), interleukin-23 (IL-23), IL-17 and IL-10.
How does this medication work?
Methotrexate, Otrexup/Rasuvo/Trexall/Xatmep is a folate antimetabolite that inhibits DNA synthesis. It interferes with DNA synthesis, repair, and replication by irreversibly binding to dihydrofolate reductase which inhibits purine and thymidylic acid synthesis. Methotrexate, Otrexup/Rasuvo/Trexall/Xatmep has also been shown to exhibit immune modulatory and anti-inflammatory activity.
How should I take this medication?
Oral: Initial: 2.5 to 5 mg/dose every 12 hours for 3 doses per week or
Oral, IM, IV, SubQ: Initial: 10 to 25 mg given once weekly; adjust dose gradually to optimal response; in general, doses >30 mg per week should not be exceeded.
Note: Some experts recommend concomitant folic acid 1 to 5 mg daily to reduce hematologic, gastrointestinal, and hepatic adverse events related to methotrexate.
How to Use Crisaborole, Eucrisa: Wash your hands before and after applying each time. For topical use only, do not apply to the eyes, eyelids, mouth, and/or mucous membranes.
What should I watch for while using this medication?
Do not use if you experience any hypersensitivity reactions including contact urticaria, severe pruritus, swelling, or erythema (at the application site or at a distant site)
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
The frequency of adverse reactions is primarily located at the site of application:
1% to 10%: Local: Application site pain (4%)
<1%: Dermatologic: Urticaria
- Choosing a selection results in a full page refresh.
- Press the space key then arrow keys to make a selection.