What is this medication?
Etanercept, Enbrel/Biosimilars (Brenzys/Erelzi)
Antirheumatic, Disease Modifying; Selective T-Cell Costimulation Blocker
Indicated for treatment of ankylosing spondylitis, plaque psoriasis, juvenile idiopathic arthritis, rheumatoid arthritis, psoriatic arthritis.
“Alert: Black Box Warning
Patients treated with etanercept are at increased risk for developing serious infections that may lead to hospitalization or death. Most patients treated with etanercept who developed these infections were taking concomitant immunosuppressants, such as methotrexate or corticosteroids.
Discontinue etanercept if a patient develops a serious infection or sepsis
Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with tumor necrosis factor (TNF) blockers, including etanercept.”
How does this medication work?
Etanercept, Enbrel/Biosimilars (Brenzys/Erelzi) is a recombinant DNA-derived protein composed of tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1. Etanercept binds tumor necrosis factor (TNF) which is an inflammatory cytokine and subsequently blocks its interaction with cell surface receptors. The suppression of TNF stops the inflammatory cascade and resulting joint and skin pathology that occurs in immune mediated arthritis and psoriasis.
How should I take this medication?
Inject 25mg to 50mg subcutaneously once to twice weekly depending on indication.
How to Take: Follow instructions provided by physician/pharmacy label, inject subcutaneously the thigh (preferred), abdomen (avoiding the 2-inch area around the navel), or outer areas of upper arm. New injections should be given at least 1 inch from an old site and never into areas where the skin is tender, bruised, red, or hard; any raised thick, red, or scaly skin patches or lesions; or areas with scars or stretch marks. For a more comfortable injection, allow autoinjectors, prefilled syringes, and dose trays to reach room temperature for 15 to 30 minutes (≥30 minutes for autoinjector) prior to injection; do not remove the needle cover while allowing product to reach room temperature. There may be small white particles of protein in the solution; this is not unusual for proteinaceous solutions.
Note: If the health care provider determines that it is appropriate, patients may self-inject after proper training in injection technique.
What should I watch for while using this medication?
Before starting Etanercept, Enbrel/Biosimilars (Brenzys/Erelzi) make sure your physician is aware of any allergies or medications you currently take, you may be at an increased risk of developing another autoimmune disorder, heart failure, cancer, and tuberculosis.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. Then, take your next dose at your regular scheduled time. In case you are not sure when to inject, call your healthcare provider. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store in the refrigerator at 2°C to 8°C. Do NOT freeze. Protect from direct sunlight, sources of heat, and humidity until ready to use. Keep the product in the original carton until the time of use.
For convenience, storage of individual syringes or SensoReady Pens at room temperature between 20°C to 25°C for up to 28 days is permissible, with protection from light and sources of heat. Once a syringe or SensoReady Pen has been stored at room temperature, it should not be placed back into the refrigerator. If not used within 28 days at room temperature, the syringe or SensoReady Pens should be discarded.
What are the possible side effects of using this medication?
Local injection site irritation, skin rash, diarrhea, positive ANA titer, antibody formation, infection, upper respiratory tract infections.
Note this is not a complete list of side effects for Etanercept, Enbrel only common ones.
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