What is this medication?
Antimigraine Agent; Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist; Monoclonal Antibody
Indicated for treatment of cluster headaches, migraine prophylaxis.
How does this medication work?
Galcanezumab, Emgality is a humanized monoclonal antibody that binds to the vasodilator calcitonin gene-related peptide (CGRP) ligand and blocks its binding to the receptor and blocks the transmission of pain in the brain.
How should I take this medication?
Usual (SubQ): 300mg at the onset of the cluster period and then once monthly until the end of the cluster period.
For prophylaxis: Initial 240 mg as a single loading dose, followed by 120 mg once monthly.
Note: Administer missed doses as soon as possible and schedule monthly from the date of the last injection.
How to Take: For subcutaneous use only; intended for self-administration. Prior to administration, allow it to come to room temperature for 30 minutes. Do not warm using a heat source. Do not shake. Administer in abdomen (avoiding 2 inches around the navel), thigh, upper arm, or buttocks avoiding areas of skin that are tender, bruised, red or hard. Deliver entire contents of single-use prefilled pen or syringe. Administer the 240 mg loading dose as 2 injections of 120 mg, one after another, and the 300 mg dose as 3 injections of 100 mg, one after another.
What should I watch for while using this medication?
Before using Galcanezumab, Emgality make sure your physician is aware of any allergies or medications you currently take, pre-existing medical conditions and activities you perform. Galcanezumab, Emgality should be used with caution in patients with who have a recent history (within 6 months) of stroke, myocardial infarction, unstable angina, percutaneous coronary intervention, coronary artery bypass grafting, deep vein thrombosis, or pulmonary embolism. Use Galcanezumab, Emgality with caution in patients with a history of stroke, intracranial or carotid aneurysm, intracranial hemorrhage, vasospastic angina or Raynaud disease.
What if I miss a dose?
If you miss a dose, inject the missed dose as soon as possible. Then inject 1 month from the date of your last dose to get back on a monthly dosing schedule. If you have questions about your schedule, ask your healthcare provider.
How should I store this medication?
Store in the refrigerator between 36°F to 46°F (2°C to 8°C). Emgality may be stored out of refrigeration in the original carton at temperatures up to 30°C (86°F) for up to 7 days. Once stored out of refrigeration, do not place back in the refrigerator. If these conditions are exceeded, the medication must be discarded.
What are the possible side effects of using this medication?
Antibody development, injection-site reaction, hypersensitivity reaction, anaphylaxis, angioedema, skin rash
Note this is not a complete list of side effects, only the most common.
- Choosing a selection results in a full page refresh.
- Press the space key then arrow keys to make a selection.