Dutasteride

What is this medication?

Dutasteride, Avodart
5 Alpha-Reductase Inhibitor

Dutasteride/Avodart is indicated for benign prostatic hyperplasia (enlarged prostate)

How does this medication work?

Dutasteride/Avodart is a modified analogue of testosterone that is a selective inhibitor of type one (in liver and skin tissue) and two (in reproductive tissue) 5 alpha-reductase.  Inhibiting 5 alpha-reductase reduces the conversion of testosterone to dihydrotestosterone which is a causative agent in benign prostatic hyperplasia (enlarged prostate).

How should I take this medication? 

Oral: 0.5mg once daily

How to Take: Follow instructions provided by physician/pharmacy label, swallow whole, take consistently at same times each day, store at room temperature

You Need to Avoid: Do not stop this medication if there is no immediate relief. This medication works by shrinking the prostate over time to increase urinary flow so be patient.

What should I watch for while using this medication? 

Before starting Dutasteride/Avodart make sure your physician is aware of any allergies, or medications you currently take, if you have liver disease, or any risk factors for prostate cancer. Investigation for obstructive uropathy should be done prior to treatment as this medication is not indicated for such.

What if I miss a dose?

If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.

How should I store this medication?

Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.

What are the possible side effects of using this medication? 

Decreased libido, gynecomastia (growth/tenderness of breast tissue in men), increase of testosterone, luteinizing hormone, and thyroid stimulating hormone, impotence 

Note this is not a complete list of side effects, only relatively common ones (under 10% of patients experience any of above).