What is this medication?
Interleukin-4 Receptor Antagonist, Monoclonal Antibody, Anti-Asthmatic
Indicated for treatment of asthma, atopic dermatitis, and rhinosinusitis (chronic) with nasal polyposis.
How does this medication work?
Dupilumab, Dupixent is a human monoclonal IgG4 antibody that inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling by specifically binding to the IL-4Rα subunit. Blocking IL-4Rα with dupilumab inhibits IL-4 and IL-13 cytokine-induced inflammatory responses, including the release of proinflammatory cytokines, chemokines, nitric oxide and IgE; however, the mechanism of Dupilumab, Dupixent action in asthma has not been definitively established.
How should I take this medication?
Usual (SubQ): Administer 600mg initial dose as two 300mg injections at different sites.
How to Take: Prior to use, do not shake, heat prefilled pen or remove the needle cap while allowing the Dupilumab, Dupixent to reach room temperature. Do not use if the solution is discolored or contains particulate matter. Neither the prefilled pen or autoinjectors have a preservative. Administer as a subcutaneous injection into the thigh or lower abdomen (avoiding within 2 inches of navel); caregiver may administer in upper arm. Rotate injection sites, including initial doses.
What should I watch for while using this medication?
Before starting Dupilumab, Dupixent, make sure your physician is aware of any allergies or medications you take and any existing medical conditions. Dupilumab, Dupixent can cause hypersensitivity reactions, including urticaria, rash, erythema nodosum, and serum sickness or serum sickness-like reactions. If you experience any signs and/or symptoms indicative of a hypersensitivity reaction discontinue Dupilumab, Dupixent immediately. In rare cases, systemic eosinophilia with clinical features of eosinophilia pneumonia or vasculitis consistent with eosinophilic granulomatosis with polyangiitis have occurred and require treatment with systemic corticosteroids. Monitor for worsening eye symptoms as conjunctivitis and keratitis have been reported. Do not use any live vaccines in patients treated with Dupilumab, Dupixent.
What if I miss a dose?
If your dose schedule is every other week: Give the injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, wait until the next scheduled dose to give your injection.
If your dose schedule is every 4 weeks and you miss a dose: Give the injection within 7 days from the missed dose, then continue with your original schedule. If the missed dose is not given within 7 days, start a new every 4 week dose schedule from the time you remember to take your injection.
How should I store this medication?
Store refrigerated at 36°F to 46°F (2°C to 8°C) in the original carton to protect from light, heat, or direct sunlight. DO NOT FREEZE. If necessary, pre-filled pens or syringes may be kept at room temperature up to 77°F (25°C) for a maximum of 14 days. Do not store above 77°F (25°C). After removal from the refrigerator, Dupixent must be used within 14 days or discarded.
What are the possible side effects of using this medication?
Antibody development, injection site reaction, gastritis, oral herpes simplex infection, toothache, herpes simplex infection, insomnia, arthralgia, conjunctivitis, oropharyngeal pain.
Note this is not a complete list of side effects, only the most common.
- Choosing a selection results in a full page refresh.
- Press the space key then arrow keys to make a selection.