What is this medication?
Doravirine+Lamivudine+Tenofovir Disoproxil Fumarate, Delstrigo
Antiretroviral, Reverse Transcriptase Inhibitor (Anti-HIV)
“Alert: US Box Warning
Doravirine, Lamivudine, Tenofovir and Disoproxil Fumarate, Delstrigo have been reported to cause an acute exacerbation of hepatitis B (HBV) in patients who are coinfected with HIV-1 and HBV and have discontinued lamivudine or tenofovir disoproxil fumarate.”
How does this medication work?
Doravirine is a non-nucleoside reverse transcriptase inhibitor that inhibits HIV-1 replication by non-competitive inhibition of HIV-1 reverse transcriptase.
Lamivudine’s primary mechanism of action is inhibiting HIV reverse transcription via viral DNA chain termination; as well as inhibiting RNA- and DNA-dependent DNA polymerase activities of reverse transcriptase.
Tenofovir disoproxil fumarate is a nucleotide reverse transcriptase inhibitor that interferes with the HIV viral RNA dependent DNA polymerase resulting in the inhibition of viral replication.
How should I take this medication?
Usual (Oral): One tablet (doravirine 100 mg/lamivudine 300 mg/tenofovir disoproxil fumarate 300 mg) once daily.
How to Take: Take with or without food.
What should I watch for while using this medication?
Before starting Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate, Delstrigo make sure your physician is aware of any allergies or medications you currently take, and current medical conditions. Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate, Delstrigo has caused serious adverse effects such as a decrease in bone mineral density, immune reconstitution syndrome, osteomalacia and renal dysfunction. Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate, Delstrigo has been associated with Hepatitis B virus exacerbation upon discontinuation of antiretroviral therapy.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Sleep disorder, dizziness, abnormal dreams, headache, impaired consciousness, insomnia, depression, suicidal tendencies, skin rash, nausea, and diarrhea.
Note this is not a complete list of side effects, only the most common.
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