What is this medication?
Skeletal Muscle Relaxant
Indicated for treatment of chronic spasticity.
“Alert: Black Box Warning
Symptomatic hepatitis (fatal and nonfatal) has been reported. Higher doses (ie, ≥800 mg/day), even sporadic short courses, may increase the risk of severe hepatic injury although hepatic injury may occur at doses <400 mg/day. Overt hepatitis has been most frequently observed between the third and twelfth month of therapy. The risk of hepatic injury appears to be greater in females, in patients >35 years, and in those taking concurrent medications. A higher incidence of fatal hepatic events have been reported in the elderly, although concurrent disease states and concurrent use of potentially hepatotoxic drugs may have contributed.”
How does this medication work?
Dantrolene, Dantrium/Revonto/Ryanodex is a muscle relaxant that blocks the release of calcium from the sarcoplasmic reticulum which will reduce myosin-actin filament cross bridging and subsequent muscle contraction.
How should I take this medication?
Oral: 25mg to 400mg once daily.
How to Take: Follow instructions provided by physician/pharmacy label, take consistently at same times each day unless otherwise directed, store at room temperature.
What should I watch for while using this medication?
Before starting Dantrolene, Dantrium/Revonto/Ryanodex make sure your physician is aware of any allergies or medications you currently take. Dantrolene, Dantrium/Revonto/Ryanodex can cause central nervous system depression (i.e. dizziness), hepatotoxicity, muscle weakness, photosensitivity and pleural effusion.
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
The frequency of side effects is not well defined but have been reported to include the following:
Flushing, atrioventricular block, tachycardia, cardiac failure, phlebitis, variable blood pressure, drowsiness, voice disorder, headache, myasthenia, chills, choking sensation, confusion, depression, fatigue, insomnia, malaise, nervousness, seizure, speech disturbance, acneiform eruption, diaphoresis, eczematous rash, erythema, hair disease (abnormal growth), pruritus, urticaria, dysphagia, nausea, vomiting, abdominal cramps, anorexia, constipation, diarrhea, dysgeusia, gastric irritation, gastrointestinal hemorrhage, sialorrhea, crystalluria, difficulty in micturition, erectile dysfunction, hematuria, nocturia, urinary frequency, urinary incontinence, urinary retention, hematologic disturbances (i.e. anemia, aplastic anemia, leukopenia, lymphocytic lymphoma, thrombocytopenia), hepatitis, injection site reaction, local tissue necrosis, blurred vision, diplopia, visual disturbance, dyspnea, pleural effusion, pulmonary edema, respiratory depression, fever.
Note this is not a complete list of side effects, only common ones.
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