What is this medication?
Officially indicated for use in thyroid disorders and for myxedema coma. It is also prescribed off-label for augmentation of antidepressant therapy, during hormonal resuscitation for cadaveric organ recovery, and for prevention of memory deficit after electroconvulsive therapy.
“ALERT: US Boxed Warning
Thyroid hormones, including liothyronine, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines, such as those used for their anorectic effects.”
How does this medication work?
The exact mechanism of action of Cytomel, Triostat/Liothyronine (T3) us unknown. T3 is naturally produced in the body through conversion of T4 in the thyroid gland. Administering exogenous T3 will help with the metabolic effects through the control of DNA transcription and protein synthesis, normal growth and development, promotion of gluconeogenesis, increased utilization and mobilization of glycogen and increase basal metabolic rate.
How should I take this medication?
Oral: Start with an initial dose of 12.5mcg to 25mcg daily; increase the dose by increments of 25mcg daily every 1 to 2 weeks.
*Conversion to Cytomel, Triostat/Liothyronine from Thyroid (desiccated) or levothyroxine: Discontinue the other medication, initiate a low dose of liothyronine and increase the dose gradually.
How Do You Take Liothyronine, Cytomel/Triostat: Take at the same time each day with or without food. Take the medication exactly as prescribed by your doctor at the same time each day.
Do Not Take Liothyronine, Cytomel/Triostat: Do not take if you have a hypersensitivity to liothyronine sodium or any component of the formulation; uncorrected adrenal insufficiency; untreated thyrotoxicosis; suffered an acute myocardial infarction
What should I watch for while using this medication?
Use with caution in patients with adrenal insufficiency
Use with caution in patients with cardiovascular disease, chronic hypothyroidism, coronary artery disease
Use with caution in patients with diabetes mellitus
Use with caution in patients with myxedema
What if I miss a dose?
If you miss a dose of medication, try to take it as soon as possible. However, if it is almost time for your next dose, take only that scheduled dose. Do not take double or extra doses.
How should I store this medication?
Keep out of the reach of children at all times. Store at room temperature, 59 to 86° F (15 to 30° C). Protect from light. Keep the container tightly closed. Properly dispose of any unused medication after the expiration date.
What are the possible side effects of using this medication?
Any side effects/adverse reactions are due to excessive thyroid replacement
1% to 10%
Cardiovascular: Cardiac arrhythmia (6%), tachycardia (3%), hypotension (<2%), myocardial infarction (<2%)
- Choosing a selection results in a full page refresh.
- Press the space key then arrow keys to make a selection.